Peckerman Arnold, LaManca John J, Dahl Kristina A, Chemitiganti Rahul, Qureishi Bushra, Natelson Benjamin H
Department of Neurosciences, CFS Cooperative Research Center, University of Medicine and Dentistry of New Jersey, Newark, NJ, USA.
Am J Med Sci. 2003 Aug;326(2):55-60. doi: 10.1097/00000441-200308000-00001.
Findings indicative of a problem with circulation have been reported in patients with chronic fatigue syndrome (CFS). We examined this possibility by measuring the patient's cardiac output and assessing its relation to presenting symptoms.
Impedance cardiography and symptom data were collected from 38 patients with CFS grouped into cases with severe (n = 18) and less severe (n = 20) illness and compared with those from 27 matched, sedentary control subjects.
The patients with severe CFS had significantly lower stroke volume and cardiac output than the controls and less ill patients. Postexertional fatigue and flu-like symptoms of infection differentiated the patients with severe CFS from those with less severe CFS (88.5% concordance) and were predictive (R2 = 0.46, P < 0.0002) of lower cardiac output. In contrast, neuropsychiatric symptoms showed no specific association with cardiac output.
These results provide a preliminary indication of reduced circulation in patients with severe CFS. Further research is needed to confirm this finding and to define its clinical implications and pathogenetic mechanisms.
据报道，慢性疲劳综合征（CFS）患者存在提示循环系统问题的表现。我们通过测量患者的心输出量并评估其与现有症状的关系来研究这种可能性。
收集了38例CFS患者的阻抗心动图和症状数据，这些患者被分为重症组（n = 18）和轻症组（n = 20），并与27名匹配的久坐对照者的数据进行比较。
重症CFS患者的每搏输出量和心输出量显著低于对照组和轻症患者。运动后疲劳和类似流感的感染症状可区分重症CFS患者和轻症CFS患者（一致性为88.5%），并可预测较低的心输出量（R2 = 0.46，P < 0.0002）。相比之下，神经精神症状与心输出量无特定关联。
这些结果初步表明重症CFS患者存在循环系统功能减退。需要进一步研究以证实这一发现，并明确其临床意义和发病机制。
