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与其他心肌病患者相比,化疗所致心肌病癌症幸存者的心律失常发生率及风险。

Rates and risk of arrhythmias in cancer survivors with chemotherapy-induced cardiomyopathy compared with patients with other cardiomyopathies.

作者信息

Fradley Michael G, Viganego Federico, Kip Kevin, Martin Angel, Patel Aarti A, Ismail-Khan Roohi, Chae Sanders, Herweg Bengt, Labovitz Arthur

机构信息

Division of Cardiovascular Medicine, University of South Florida, Tampa, Florida, USA.

Cardio-Oncology Program, H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA.

出版信息

Open Heart. 2017 Dec 17;4(2):e000701. doi: 10.1136/openhrt-2017-000701. eCollection 2017.

DOI:10.1136/openhrt-2017-000701
PMID:29344369
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5761288/
Abstract

OBJECTIVES

There is little information about arrhythmia burden in cancer survivors with chemotherapy-induced cardiomyopathy (CIC). We hypothesise that the rates and risk of arrhythmias will be similar in CIC when compared with other non-ischaemic cardiomyopathy (NICMO) aetiologies.

METHODS

We retrospectively identified nine patients with CIC and an implantable defibrillator and 18 age and sex-matched control patients (nine patients with NICMO and nine patients with ischaemic cardiomyopathy (ICMO)). Rates and odds of arrhythmias were calculated by type of cardiomyopathy, adjusting for days since implantable cardioverter defibrillator implantation, history of atrial fibrillation and length of follow-up using logistic regression analysis.

RESULTS

Compared with patients with NICMO, rates and adjusted odds were similar for patients with CIC for atrial arrhythmias (44.4% vs 33.3%; adjusted OR=1.89; 95% CI0.17 to 21.03; P=0.61), non-sustained ventricular tachycardia (NSVT) (44.4% vs 33.3%; OR=2.10; 95% CI 0.21 to 20.56; P=0.53), and the combined outcome of NSVT, sustained ventricular tachycardia and/or ventricular fibrillation (44.4% vs 44.4%; OR=2.70; 95% CI 0.25 to 29.48; P=0.42). Conversely, compared with patients with NICMO, patients with ICMO demonstrated higher rates and adjusted odds of the combined outcome (88.9% vs 44.4%; OR=28.60; 95% CI 1.26 to 648.2; P=0.04) and NSVT (77.8% vs 33.3%; OR=8.95; 95% CI 0.90 to 88.94; P=0.06).

CONCLUSIONS

While tentative based on sample size, rates of arrhythmias in patients with CIC appear to be similar to those experienced by patients with other forms of NICMO.

摘要

目的

关于化疗所致心肌病(CIC)癌症幸存者的心律失常负担,相关信息较少。我们假设,与其他非缺血性心肌病(NICMO)病因相比,CIC患者的心律失常发生率和风险相似。

方法

我们回顾性纳入了9例植入了除颤器的CIC患者以及18例年龄和性别匹配的对照患者(9例NICMO患者和9例缺血性心肌病(ICMO)患者)。根据心肌病类型计算心律失常的发生率和比值比,并使用逻辑回归分析对自植入式心脏复律除颤器植入后的天数、房颤病史和随访时间进行校正。

结果

与NICMO患者相比,CIC患者房性心律失常的发生率和校正后的比值比相似(44.4%对33.3%;校正后OR=1.89;95%CI 0.17至21.03;P=0.61),非持续性室性心动过速(NSVT)(44.4%对33.3%;OR=2.10;95%CI 0.21至20.56;P=0.53),以及NSVT、持续性室性心动过速和/或室颤的综合结果(44.4%对44.4%;OR=2.70;95%CI 0.25至29.48;P=0.42)。相反,与NICMO患者相比,ICMO患者的综合结果(88.9%对44.4%;OR=28.60;95%CI 1.26至648.2;P=0.04)和NSVT(77.8%对33.3%;OR=8.95;95%CI 0.90至88.94;P=0.06)的发生率和校正后的比值比更高。

结论

尽管基于样本量得出的结论具有初步性,但CIC患者的心律失常发生率似乎与其他形式NICMO患者的发生率相似。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/573b/5761288/5ff6f3778d25/openhrt-2017-000701f01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/573b/5761288/5ff6f3778d25/openhrt-2017-000701f01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/573b/5761288/5ff6f3778d25/openhrt-2017-000701f01.jpg

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本文引用的文献

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2
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N Engl J Med. 2016 Sep 29;375(13):1221-30. doi: 10.1056/NEJMoa1608029. Epub 2016 Aug 27.
3
2016 ESC Position Paper on cancer treatments and cardiovascular toxicity developed under the auspices of the ESC Committee for Practice Guidelines:  The Task Force for cancer treatments and cardiovascular toxicity of the European Society of Cardiology (ESC).
Biomimetic Nanozymes Suppressed Ferroptosis to Ameliorate Doxorubicin-Induced Cardiotoxicity via Synergetic Effect of Antioxidant Stress and GPX4 Restoration.
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Nutrients. 2023 Feb 22;15(5):1090. doi: 10.3390/nu15051090.
4
Maternal Cardiovascular Outcomes of Pregnancy in Childhood, Adolescent, and Young Adult Cancer Survivors.儿童、青少年和年轻成年癌症幸存者孕期的母亲心血管结局
J Cardiovasc Dev Dis. 2022 Oct 31;9(11):373. doi: 10.3390/jcdd9110373.
5
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JACC CardioOncol. 2020 Dec 15;2(5):747-754. doi: 10.1016/j.jaccao.2020.09.008. eCollection 2020 Dec.
6
Recognition, Prevention, and Management of Arrhythmias and Autonomic Disorders in Cardio-Oncology: A Scientific Statement From the American Heart Association.心律失常和心脏肿瘤自主神经障碍的识别、预防和管理:美国心脏协会的科学声明。
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5
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8
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9
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10
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