Winkelmann R K
J Cutan Pathol. 1985 Dec;12(6):486-92. doi: 10.1111/j.1600-0560.1985.tb00447.x.
Twelve patients with dermographism were studied by histological examination. Six spontaneous lesion showed perivascular lymphocytosis. Biopsy of 6 induced lesions showed neutrophiles at 15-30 min and lymphocytes at 1 h or more. One patient biopsied both at 15 min and 2 h showed both microscopic pictures successively. Immunofluorescence of spontaneous or induced lesions in 5 patients was not significant. Studies of T cell subsets of an induced lesion at 30 min showed a moderate number of T helper cells. Mast cell and eosinophile changes were not important. These studies of dermographism imply successive changes with time in perivascular cellular pathology.
对12例人工荨麻疹患者进行了组织学检查。6例自发性皮损显示血管周围淋巴细胞增多。6例诱发皮损活检显示，15 - 30分钟时出现中性粒细胞，1小时及更长时间出现淋巴细胞。1例患者在15分钟和2小时时均进行了活检，先后出现了两种显微镜下表现。5例患者自发性或诱发性皮损的免疫荧光检查无明显异常。对30分钟时的1例诱发皮损进行T细胞亚群研究，显示有中等数量的辅助性T细胞。肥大细胞和嗜酸性粒细胞变化不明显。这些人工荨麻疹研究提示，血管周围细胞病理学随时间发生连续变化。
