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以干眼症为表现的原发性结膜结核:1例罕见病例报告及文献复习

Primary Conjunctival Tuberculosis Presenting as Dry Eye: A Rare Case Report and Review of the Literature.

作者信息

Brar Rupinder Kaur, Singh Ashok, Deshpande Archana Hemant, Gargade Chitrawati Bal, Das Sujit

机构信息

Department of Pathology, Andaman and Nicobar Islands Institute of Medical Sciences (ANIIMS), Port Blair, India.

Department of Ophthalmology, Andaman and Nicobar Islands Institute of Medical Sciences (ANIIMS), Port Blair, India.

出版信息

Ocul Oncol Pathol. 2017 Nov;3(4):276-278. doi: 10.1159/000464467. Epub 2017 Apr 7.

Abstract

Primary conjunctival tuberculosis is very rare in the developed countries. In an endemic country like India, it should be considered in the differential diagnosis of any unusual conjunctival lesion with unilaterality, chronicity, and nonresolution of symptoms after steroid use. We present the case of a 52-year-old female who presented with unilateral itching and blurring of vision for 20 days. There were irregular nodular elevated areas with shrinkage of the lower palpebral conjunctiva. A biopsy of the lesion revealed necrotizing epithelioid cell granulomas along with Langhans type of giant cells. However, no acid-fast bacilli were seen on Ziehl-Neelsen stain. Systemic examination of the patient was normal, and there was no evidence of pulmonary tuberculosis. Polymerase chain reaction of conjunctival scrapings was positive for . The patient was started on antitubercular drugs. We present this very rare case of primary tuberculosis of the conjunctiva presenting with dryness of the eye.

摘要

原发性结膜结核在发达国家非常罕见。在像印度这样的地方病流行国家,对于任何具有单侧性、慢性且使用类固醇后症状未缓解的异常结膜病变,都应考虑将原发性结膜结核纳入鉴别诊断。我们报告一例52岁女性病例,该患者出现单侧眼部瘙痒和视力模糊20天。下睑结膜有不规则结节状隆起区域并伴有萎缩。病变活检显示坏死性上皮样细胞肉芽肿以及朗汉斯型巨细胞。然而,萋-尼染色未发现抗酸杆菌。患者的全身检查正常,也没有肺结核的证据。结膜刮片的聚合酶链反应呈阳性。患者开始接受抗结核药物治疗。我们报告了这例非常罕见的以眼干为表现的原发性结膜结核病例。

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本文引用的文献

2
Primary tuberculosis of the conjunctiva.结膜原发性结核
Am J Dis Child (1911). 1946 Aug;72:211-5. doi: 10.1001/archpedi.1946.02020310077007.
4
Primary tuberculosis of the conjunctiva.
Eye (Lond). 2001 Oct;15(Pt 5):674-6. doi: 10.1038/eye.2001.215.

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