情感障碍中的一碳代谢紊乱：初步报告

One-carbon metabolism disturbances in affective disorders. A preliminary report.

作者信息

Alarcon R D, Tolbert L C, Monti J A, Morere D A, Walter-Ryan W G, Kemp B, Smythies J R

出版信息

J Affect Disord. 1985 Nov;9(3):297-301. doi: 10.1016/0165-0327(85)90060-6.

Abstract

Methionine adenosyltransferase (MAT) activity (Vmax) and the relative amount of phosphatidylcholine (% PC) were measured in erythrocytes of up to 30 DSM-III diagnosed manic, 17 unipolar depressed patients, and 28 normal controls. Manic subjects had significantly higher and depressed subjects significantly lower MAT Vmax than normals. The relative amount of PC was in the low range for the depressives, and in the high range for the manics. Depressive patients present, in these tests, similar abnormalities to those seen previously in schizophrenic patients. Clinical and diagnostic implications of these findings are discussed.

摘要

对多达30名经《精神疾病诊断与统计手册》第三版诊断为躁狂症的患者、17名单相抑郁症患者和28名正常对照者的红细胞进行了蛋氨酸腺苷转移酶（MAT）活性（Vmax）和磷脂酰胆碱相对含量（%PC）的测定。躁狂症患者的MAT Vmax显著高于正常对照组，而抑郁症患者则显著低于正常对照组。抑郁症患者的PC相对含量处于低水平，而躁狂症患者则处于高水平。在这些测试中，抑郁症患者呈现出与先前在精神分裂症患者中观察到的类似异常。讨论了这些发现的临床和诊断意义。