一碳代谢异常的临床关联

Clinical correlations of one-carbon metabolism abnormalities.

Tolbert L C, Monti J A, Walter-Ryan W, Alarcon R D, Bahar B, Keriotis J T, Allison J G, Cates A, Antun F, Smythies J R

Department of Psychiatry, University of Alabama, Birmingham.

Prog Neuropsychopharmacol Biol Psychiatry. 1988;12(4):491-502. doi: 10.1016/0278-5846(88)90108-x.

Abstract

Ninety psychiatric inpatients with a DSM III diagnosis of schizophrenia, mania, or major depression were studied. 2. Upon admission/transfer to the Clinical Studies Unit, and prior to discharge, measurements of symptom severity (BPRS, Ham-D, Young's Mania Scale) and blood samples were obtained. 3. Erythrocytes from these paired (admission and discharge) blood samples were assayed for methionine adenosyltransferase (MAT) activity and phosphatidylcholine (PC) content. 4. Comparisons were made between the changes in MAT Vmax, or % PC, and changes in symptom severity. 5. For the majority of the patients (79.3% of the schizophrenics; 84.6% of the depressives; and 93.8% of the manics), clinical improvement was associated with a "normalization" of enzyme activity. The association between changes in % PC and clinical response did not achieve significant correlation.

摘要

对90名被诊断为精神分裂症、躁狂症或重度抑郁症的精神科住院患者进行了研究。2. 在入院/转入临床研究室时以及出院前，获取症状严重程度（简明精神病评定量表、汉密尔顿抑郁量表、杨氏躁狂量表）的测量值和血样。3. 对这些配对（入院和出院时）血样中的红细胞进行蛋氨酸腺苷转移酶（MAT）活性和磷脂酰胆碱（PC）含量的检测。4. 对MAT Vmax或PC百分比的变化与症状严重程度的变化进行比较。5. 对于大多数患者（79.3%的精神分裂症患者；84.6%的抑郁症患者；93.8%的躁狂症患者），临床改善与酶活性的“正常化”相关。PC百分比变化与临床反应之间的关联未达到显著相关性。