糖尿病生物繁殖/伍斯特（BB/Wor）大鼠不一定需要淋巴细胞减少。
Diabetic BioBreeding/Worcester (BB/Wor) rats need not be lymphopenic.
作者信息
Like A A, Guberski D L, Butler L
出版信息
J Immunol. 1986 May 1;136(9):3254-8.
The BB/Wor rat is an animal model of spontaneous autoimmune type I diabetes mellitus. Previous reports have emphasized the presence of lymphopenia in all diabetic and diabetes-prone BB rats. This manuscript reports the appearance of diabetes among three family lines of BB/Wor animals that were previously free of diabetes. Diabetic W-line rats are not lymphopenic and possess normal percentages of phenotypic T cell subsets. Hence the presence of lymphopenia is not obligatory for the occurrence of diabetes in BB/Wor rats.
BB/Wor大鼠是自发性自身免疫性I型糖尿病的动物模型。先前的报告强调，所有患糖尿病和易患糖尿病的BB大鼠都存在淋巴细胞减少的情况。本手稿报告了三个先前无糖尿病的BB/Wor动物家系中出现糖尿病的情况。患糖尿病的W系大鼠不存在淋巴细胞减少，且表型T细胞亚群的百分比正常。因此，淋巴细胞减少并非BB/Wor大鼠发生糖尿病的必要条件。
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