Greiner D L, Handler E S, Nakano K, Mordes J P, Rossini A A
J Immunol. 1986 Jan;136(1):148-51.
Diabetes-prone Bio-breeding/Worcester (DP) rats exhibit a severe T cell lymphopenia and autoimmune pancreatic insulitis. The present results indicate that the T cell lymphopenia is due in large part, if not entirely, to the absence of the RT-6+ peripheral T cell subset, which includes members of both the helper/inducer (W3/25) and suppressor/cytotoxic (OX 8) antigenic phenotypes. Delineation of the causal mechanism(s) for the selective absence of RT-6+ T cells in DP rats may provide important insights into the cellular basis of the insulin-dependent diabetes mellitus syndrome in these animals.
易患糖尿病的生物繁殖/伍斯特（DP）大鼠表现出严重的T细胞淋巴细胞减少和自身免疫性胰腺胰岛炎。目前的结果表明，T细胞淋巴细胞减少在很大程度上（如果不是完全的话）是由于缺乏RT-6⁺外周T细胞亚群，该亚群包括辅助/诱导（W3/25）和抑制/细胞毒性（OX 8）抗原表型的成员。阐明DP大鼠中RT-6⁺ T细胞选择性缺失的因果机制可能为这些动物胰岛素依赖型糖尿病综合征的细胞基础提供重要见解。
