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野生型和干扰素抗性人淋巴母细胞（Daudi细胞）中干扰素诱导的基因表达。

Interferon-induced gene expression in wild-type and interferon-resistant human lymphoblastoid (Daudi) cells.

作者信息

McMahon M, Stark G R, Kerr I M

出版信息

J Virol. 1986 Jan;57(1):362-6. doi: 10.1128/JVI.57.1.362-366.1986.

DOI:10.1128/JVI.57.1.362-366.1986
PMID:2934555
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC252737/
Abstract

Interferon-induced gene expression was analyzed in wild-type and interferon-resistant Daudi cells. Two classes of alpha-interferon-induced mRNAs and proteins were observed: those that were similarly induced in both types of cell and those that were induced only in the wild-type cells. Furthermore, the level of c-myc mRNA decreased in the wild-type but not in the resistant cells. This differential control in the wild-type and resistant cells indicates that there must be either functionally distinct alpha-interferon receptors or more than one pathway leading to altered gene expression triggered by a single receptor.

摘要

在野生型和对干扰素耐药的Daudi细胞中分析了干扰素诱导的基因表达。观察到两类α-干扰素诱导的mRNA和蛋白质：一类在两种细胞中诱导情况相似，另一类仅在野生型细胞中被诱导。此外，c-myc mRNA水平在野生型细胞中下降，但在耐药细胞中未下降。野生型和耐药细胞中的这种差异调控表明，必定存在功能不同的α-干扰素受体，或者存在一条以上由单一受体触发导致基因表达改变的途径。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c65/252737/7c88e53f3514/jvirol00112-0383-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c65/252737/4174b7ffdfe4/jvirol00112-0381-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c65/252737/ae979903df60/jvirol00112-0382-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c65/252737/7c88e53f3514/jvirol00112-0383-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c65/252737/4174b7ffdfe4/jvirol00112-0381-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c65/252737/ae979903df60/jvirol00112-0382-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c65/252737/7c88e53f3514/jvirol00112-0383-a.jpg

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本文引用的文献

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Selective reduction of c-myc mRNA in Daudi cells by human beta interferon.人β干扰素对Daudi细胞中c-myc信使核糖核酸的选择性降低作用
Proc Natl Acad Sci U S A. 1984 Mar;81(6):1747-50. doi: 10.1073/pnas.81.6.1747.
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Transcriptional analyses of interferon-inducible mRNAs.干扰素诱导mRNA的转录分析。
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Transcriptional induction of two genes in human cells by beta interferon.β干扰素对人类细胞中两个基因的转录诱导作用。
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