Kwon Ji Ye, Lee Seung Hoon, Jhun JooYeon, Choi JeongWon, Jung KyungAh, Cho Keun Hyung, Kim Seok Jung, Yang Chul Woo, Park Sung-Hwan, Cho Mi-La
1 The Rheumatism Research Center, Catholic Research Institute of Medical Science, College of Medicine, The Catholic University of Korea , Seoul, Korea.
2 Impact Biotech , Seoul, Korea.
J Med Food. 2018 Apr;21(4):364-371. doi: 10.1089/jmf.2017.4034. Epub 2018 Jan 18.
Osteoarthritis (OA), a degenerative disorder, induces pain, joint inflammation, and destruction of the articular cartilage matrix. Probiotic complex, rosavin, and zinc have been used as dietary supplements that exhibit anti-inflammatory and antioxidant properties. However, there is no evidence demonstrating a synergic effect in OA. This study aims to determine whether combination with probiotic complex, rosavin, and zinc decreases progression of monosodium iodoacetate (MIA)-induced OA rat model. The combination improved pain levels by preventing cartilage damage. The expression of proinflammatory cytokines and catabolic factors was reduced by the combination within the joint tissue. However, the combination increased anti-inflammatory cytokines as well as the anabolic factor production. The gene level of catabolic factors was decreased with treatment of the combination in chondrocytes isolated from OA patients. These results suggest that the combination can improve MIA development through the inhibition of proinflammatory cytokines and cartilage destruction, thus playing a key role as a therapeutic candidate for OA treatment.
骨关节炎（OA）是一种退行性疾病，可引发疼痛、关节炎症以及关节软骨基质破坏。益生菌复合物、红景天苷和锌已被用作具有抗炎和抗氧化特性的膳食补充剂。然而，尚无证据表明其在骨关节炎中具有协同作用。本研究旨在确定益生菌复合物、红景天苷和锌联合使用是否能减缓碘乙酸钠（MIA）诱导的骨关节炎大鼠模型的病情进展。联合用药通过防止软骨损伤改善了疼痛程度。联合用药降低了关节组织中促炎细胞因子和分解代谢因子的表达。然而，联合用药增加了抗炎细胞因子以及合成代谢因子的产生。在从骨关节炎患者分离出的软骨细胞中，联合用药治疗降低了分解代谢因子的基因水平。这些结果表明，联合用药可通过抑制促炎细胞因子和软骨破坏来改善MIA诱导的骨关节炎病情发展，从而作为骨关节炎治疗的候选疗法发挥关键作用。
