Abboud Jean-Paul J, Whittington Alexander, Ahmed Masih, Himebaugh Jesse T, Wiley Lee A, Haffar Ahmad, Nguyen John
Department of Ophthalmology, School of Medicine, West Virginia University.
West Virginia University.
Ophthalmic Plast Reconstr Surg. 2018 May/Jun;34(3):e76-e77. doi: 10.1097/IOP.0000000000001047.
Ichthyosis is a cutaneous disorder characterized by excessive amounts of dry thickened skin surface scales. Ocular manifestations of ichthyosis include cicatricial ectropion, which may cause exposure keratoconjunctivitis and rarely corneal perforation. Topical emollients, anti-inflammatory ointments, and systemic retinoids have been used to control the disease process, while surgical correction with donor graft has been reserved for severe cases involving corneal exposure. The authors report a case of a Caucasian male with lamellar ichthyosis with severe bilateral upper and lower eyelid cicatricial ectropion and corneal ulceration requiring surgical correction. Treatment with apremilast, a novel phosphodiesterase-4 inhibitor, for the treatment of a concomitant plaque psoriasis achieved good control of his skin diseases and minimized the recurrence of eyelid ectropion.
鱼鳞病是一种皮肤疾病，其特征是皮肤表面有大量干燥增厚的鳞屑。鱼鳞病的眼部表现包括瘢痕性睑外翻，这可能导致暴露性角膜结膜炎，很少会导致角膜穿孔。外用润肤剂、抗炎软膏和全身性维甲酸已被用于控制病情发展，而对于涉及角膜暴露的严重病例，则采用供体移植进行手术矫正。作者报告了一例患有板层状鱼鳞病的白种男性病例，该患者双侧上下眼睑严重瘢痕性睑外翻并伴有角膜溃疡，需要进行手术矫正。使用新型磷酸二酯酶-4抑制剂阿普斯特治疗伴发的斑块状银屑病，很好地控制了他的皮肤疾病，并使眼睑外翻的复发率降至最低。
