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美国老年成年人开始血液透析后严重跌倒损伤史与不良健康结局。

Serious Fall Injury History and Adverse Health Outcomes After Initiating Hemodialysis Among Older U.S. Adults.

机构信息

Durham Veterans Affairs Geriatric Research Education and Clinical Center, Durham Veterans Affairs Medical Center (VAMC), North Carolina.

Divison of Geriatric Medicine, Department of Medicine, Duke University, Durham, North Carolina.

出版信息

J Gerontol A Biol Sci Med Sci. 2018 Aug 10;73(9):1216-1221. doi: 10.1093/gerona/glx260.

Abstract

BACKGROUND

Although older adults with predialysis chronic kidney disease are at higher risk for falls, the prognostic significance of a serious fall injury prior to dialysis initiation has not been well described in the end-stage renal disease population.

METHODS

We examined the association between a serious fall injury in the year prior to starting hemodialysis and adverse health outcomes in the year following dialysis initiation using a retrospective cohort study of U.S. Medicare beneficiaries ≥ 67 years old who initiated dialysis in 2010-2012. Serious fall injuries were defined using diagnostic codes for falls plus an injury (fracture, joint dislocation, or head injury). Health outcomes, defined as time-to-event variables within the first year of dialysis, included four outcomes: a subsequent serious fall injury, hospital admission, post-acute skilled nursing facility (SNF) utilization, and mortality.

RESULTS

Among this cohort of 81,653 initiating hemodialysis, 2,958 (3.6%) patients had a serious fall injury in the year prior to hemodialysis initiation. In the first year of dialysis, 7.6% had a subsequent serious fall injury, 67.6% a hospitalization, 30.7% a SNF claim, and 26.1% died. Those with versus without a serious fall injury in the year prior to hemodialysis initiation were at higher risk (hazard ratio, 95% confidence interval) for a subsequent serious fall injury (2.65, 2.41-2.91), hospitalization (1.11, 1.06-1.16), SNF claim (1.40, 1.30-1.50), and death (1.14, 1.06-1.22).

CONCLUSIONS

For older adults initiating dialysis, a history of a serious fall injury may provide prognostic information to support decision making and establish expectations for life after dialysis initiation.

摘要

背景

尽管透析前慢性肾脏病的老年患者发生跌倒的风险更高,但在终末期肾病患者中,透析前一年内发生严重跌倒损伤对预后的影响尚未得到充分描述。

方法

我们使用美国 Medicare 受益人的回顾性队列研究,对 2010-2012 年期间开始透析的≥67 岁患者进行了研究,调查了在开始血液透析前一年发生严重跌倒损伤与透析后一年内不良健康结局之间的关系。严重跌倒损伤是通过跌倒加损伤的诊断代码(骨折、关节脱位或头部损伤)来定义的。健康结局是指在透析的第一年中作为时间相关变量的四个结局:随后发生严重跌倒损伤、住院、急性后康复护理机构(SNF)利用和死亡。

结果

在这个接受血液透析的 81653 例队列中,2958 例(3.6%)患者在开始血液透析前一年发生了严重的跌倒损伤。在透析的第一年中,7.6%的患者随后发生了严重跌倒损伤,67.6%的患者住院,30.7%的患者入住 SNF,26.1%的患者死亡。与透析前一年没有严重跌倒损伤的患者相比,这些患者发生随后的严重跌倒损伤(危险比,95%置信区间)、住院(1.11,1.06-1.16)、入住 SNF(1.40,1.30-1.50)和死亡(1.14,1.06-1.22)的风险更高。

结论

对于开始透析的老年患者,严重跌倒损伤的病史可能提供预后信息,以支持决策并为透析后生活建立预期。

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