Jabbari Masoumeh, Kheirouri Sorayya, Alizadeh Mohammad
Department of Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran.
Lab Med. 2018 Mar 21;49(2):140-146. doi: 10.1093/labmed/lmx087.
We aimed to investigate the association between serum levels of ghrelin and brain-derived neurotrophic factor (BDNF) with MetS and its components in premenopausal women.
43 patients with MetS and 43 healthy controls participated in this study. Participants' body mass index (BMI), waist circumference (WC), systolic and diastolic blood pressure (SBP and DBP) were measured. Serum levels of total cholesterol (TC), triglyceride (TG), low and high density lipoprotein cholesterol (LDL-C and HDL-C), fasting blood sugar (FBS), insulin, BDNF and ghrelin determined. Homeostasis model assessment insulin resistance index (HOMA-IR) was also calculated.
Participants in MetS group had higher waist-to-hip ratios, elevated SBP and DBP, and higher serum levels of TG, FBS and insulin when compared with the control group. Serum ghrelin and BDNF levels were significantly lower in participants with MetS than in the healthier control subjects. There was a strong, positive correlation between serum ghrelin and BDNF levels. Both proteins negatively correlated with TG, FBS, HOMA-IR and positively with HDL-C. Furthermore, serum BDNF levels negatively associated with insulin levels.
The findings indicate that variations occur in the circulating level of ghrelin and BDNF proteins in MetS patients. A strong correlation between serum ghrelin and BDNF suggests that production, release or practice of these 2 proteins might be related mechanically.
我们旨在研究绝经前女性血清中胃饥饿素和脑源性神经营养因子（BDNF）水平与代谢综合征（MetS）及其组分之间的关联。
43例代谢综合征患者和43名健康对照者参与了本研究。测量了参与者的体重指数（BMI）、腰围（WC）、收缩压和舒张压（SBP和DBP）。测定了血清总胆固醇（TC）、甘油三酯（TG）、低密度和高密度脂蛋白胆固醇（LDL-C和HDL-C）、空腹血糖（FBS）、胰岛素、BDNF和胃饥饿素水平。还计算了稳态模型评估胰岛素抵抗指数（HOMA-IR）。
与对照组相比，代谢综合征组参与者的腰臀比更高、SBP和DBP升高，血清TG、FBS和胰岛素水平更高。代谢综合征患者的血清胃饥饿素和BDNF水平显著低于健康对照者。血清胃饥饿素和BDNF水平之间存在强正相关。两种蛋白均与TG、FBS、HOMA-IR呈负相关，与HDL-C呈正相关。此外，血清BDNF水平与胰岛素水平呈负相关。
研究结果表明，代谢综合征患者循环中胃饥饿素和BDNF蛋白水平发生了变化。血清胃饥饿素和BDNF之间的强相关性表明这两种蛋白的产生、释放或作用机制可能相关。
