Students' Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Community Nutrition, School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical Sciences, PO Box 81745-151, Isfahan, Iran.
Sci Rep. 2021 Jul 2;11(1):13773. doi: 10.1038/s41598-021-93271-z.
Several epidemiologic studies have evaluated the relation between serum/plasma brain-derived neurotrophic factor (BDNF) levels and glycemic parameters, but the findings were conflicting. We performed a systematic review and meta-analysis to compare circulating BDNF levels in individuals with type 2 diabetes (T2D) or other glycemic disorders with healthy controls and to evaluate correlation between BDNF concentrations with glycemic profile. A systematic search up to July 2020 was conducted in reliable electronic databases (MEDLINE (Pubmed), EMBASE, Scopus) and Google scholar. Sixteen observational studies compared serum/plasma BDNF levels in diabetic patients (or individuals with glycemic disorders) vs. healthy controls or reported correlations between serum BDNF levels and glycemic parameters in adults were included in the review. Overall weighted mean difference (WMD) of circulating BDNF levels in 1306 patients with T2D (or other glycemic disorders) was 1.12 ng/mL lower than 1250 healthy subjects (WMD: - 1.12; 95%CI - 1.37, - 0.88, I = 98.7%, P < 0.001). Subgroup analysis revealed that both diabetic patients and subjects with other glycemic disorders had lower serum/plasma BDNF levels than healthy controls (WMD: - 1.74; 95%CI - 2.15, - 1.33 and WMD: - 0.49; 95%CI - 0.82, - 0.16, respectively). No significant correlation was found between BDNF levels and glycemic parameters [fasting blood glucose (FBG) (Fisher's Z = 0.05; 95%CI - 0.21, 0.11; n = 1400), homeostatic model assessment for insulin resistance (HOMA-IR) (Fisher's Z = 0.12; 95%CI - 0.20, 0.44; n = 732) and glycosylated hemoglobin (HbA1c) (Fisher's Z = 0.04; 95%CI - 0.05, 0.12; n = 2222)]. We found that diabetic patients and subjects with glycemic disorders had lower circulating BDNF levels than healthy controls. However, there was no significant correlation between BDNF concentrations and glycemic parameters including FBG, HOMA-IR and HbA1c. Further prospective investigations are required to confirm these findings.
几项流行病学研究评估了血清/血浆脑源性神经营养因子（BDNF）水平与血糖参数之间的关系，但结果存在矛盾。我们进行了系统评价和荟萃分析，以比较 2 型糖尿病（T2D）或其他血糖紊乱患者与健康对照者的循环 BDNF 水平，并评估 BDNF 浓度与血糖谱之间的相关性。截至 2020 年 7 月，在可靠的电子数据库（MEDLINE（PubMed）、EMBASE、Scopus）和 Google Scholar 中进行了系统搜索。综述纳入了 16 项比较糖尿病患者（或血糖紊乱者）与健康对照者血清/血浆 BDNF 水平的观察性研究，或报告了成人血清 BDNF 水平与血糖参数之间相关性的研究。1306 例 T2D（或其他血糖紊乱）患者的循环 BDNF 水平总体加权均数差（WMD）比 1250 例健康受试者低 1.12ng/mL（WMD：-1.12；95%CI-1.37，-0.88，I=98.7%，P<0.001）。亚组分析显示，糖尿病患者和其他血糖紊乱患者的血清/血浆 BDNF 水平均低于健康对照组（WMD：-1.74；95%CI-2.15，-1.33 和 WMD：-0.49；95%CI-0.82，-0.16）。BDNF 水平与血糖参数之间无显著相关性[空腹血糖（FBG）（Fisher's Z=0.05；95%CI-0.21，0.11；n=1400）、稳态模型评估的胰岛素抵抗（HOMA-IR）（Fisher's Z=0.12；95%CI-0.20，0.44；n=732）和糖化血红蛋白（HbA1c）（Fisher's Z=0.04；95%CI-0.05，0.12；n=2222]。我们发现，糖尿病患者和血糖紊乱患者的循环 BDNF 水平低于健康对照组。然而，BDNF 浓度与 FBG、HOMA-IR 和 HbA1c 等血糖参数之间无显著相关性。需要进一步的前瞻性研究来证实这些发现。
