Department of Neuroscience, Tufts University School of Medicine, Boston, MA 02111, USA.
Department of Neuroscience, Tufts University School of Medicine, Boston, MA 02111, USA.
Neuron. 2018 Jan 17;97(2):253-255. doi: 10.1016/j.neuron.2018.01.002.
Madry et al. (2018) show that the two-pore potassium channel THIK-1 is tonically active in microglia and promotes microglial ramification and surveillance of the brain parenchyma. Interestingly, THIK-1 is not essential to damage-induced outgrowth of microglial processes but is critical to microglial IL-1β release.
马德里等人（2018 年）表明，双孔钾通道 THIK-1 在小胶质细胞中呈紧张性激活状态，促进小胶质细胞的分支和大脑实质的监视。有趣的是，THIK-1 对于损伤诱导的小胶质细胞突起生长不是必需的，但对于小胶质细胞释放白细胞介素-1β是至关重要的。
