Department of Medical Laboratory Science, College of Medicine and Health Sciences, Wollo University, P.O. Box 1145, Dessie, Ethiopia.
BMC Infect Dis. 2018 Jun 7;18(1):260. doi: 10.1186/s12879-018-3179-5.
Helicobacter pylori (H. pylori) infection is the most common chronic bacterial infection in the world. It can result in various upper gastroduodenal diseases. The prevalence varies among countries, population groups within the same country and testing methods. The aim of the study was to determine feco-prevalence and risk factors of H.pylori infection among symptomatic patients in Amhara region, Northeast Ethiopia.
A cross sectional study was conducted in a total of 342 new consecutive outpatients with upper abdominal complaints at Dessie Referral Hospital from May to July, 2016. A structured questionnaire was used to collect the socio-demographic, lifestyle and environmental data. Stool samples were used to detect H. pylori specific antigen. Blood samples were assessed for anti-H. pylori IgG and ABO blood types. SPSS version 20.0 statistical software package was used for data analysis. Chi-square test and logistic regression were used in the analysis and P-value ≤0.05 was considered as statistically significant.
H. pylori stool antigen and serum anti-H.pylori IgG detection rate was 30.4 and 60.5% respectively with kappa measure of agreement of 0.271. Antigen detection was significantly associated with family size (> 3) [AOR = 1.83, 95% CI: 1.10-3.05, p = 0.02], more persons (> 3) sharing the same bed room in the household [AOR = 2.91, 95% CI: 1.39-6.11, p = 0.005], alcohol consumption (> once a week) [AOR = 2.70, 95% CI: 1.49-4.89, p = 0.001] and individuals' blood type: group O [AOR = 8.93, 95%CI: 1.79-44.48, p = 0.008] and group A [AOR = 5.53, 95%CI: 1.08-28.36, p = 0.040]. Gender, age, marital status, occupation, educational level, residence, smoking as well as coffee, tea, fruits and vegetables consumption were not statistically associated with H. pylori antigen detection (p > 0.05).
The overall H. pylori stool antigen and anti-H. pylori IgG detection rate was 30.4 and 60.5%, respectively. The test agreement was not strongly convincing and needs further evaluation. Alcohol consumption, overcrowding and ABO blood group were significantly associated with H. pylori antigen detection.
幽门螺杆菌（H. pylori）感染是世界上最常见的慢性细菌性感染。它可导致各种上胃肠道疾病。其流行率因国家、同一国家内的人群以及检测方法而异。本研究旨在确定埃塞俄比亚东北部阿姆哈拉地区有症状患者中 H.pylori 感染的粪便流行率和危险因素。
2016 年 5 月至 7 月，在德西转诊医院共对 342 名新连续出现上腹部症状的门诊患者进行了横断面研究。使用结构化问卷收集社会人口统计学、生活方式和环境数据。使用粪便样本检测 H. pylori 特异性抗原。评估血液样本中的抗 H. pylori IgG 和 ABO 血型。使用 SPSS 版本 20.0 统计软件包进行数据分析。卡方检验和逻辑回归用于分析，P 值≤0.05 被认为具有统计学意义。
H. pylori 粪便抗原和血清抗 H.pylori IgG 检测率分别为 30.4%和 60.5%，一致性kappa 测量值为 0.271。抗原检测与家庭规模（>3 人）显著相关 [比值比（AOR）=1.83，95%置信区间（CI）：1.10-3.05，p=0.02]，更多人（>3 人）在同一卧室中共享床位 [AOR=2.91，95%CI：1.39-6.11，p=0.005]，饮酒（每周>1 次）[AOR=2.70，95%CI：1.49-4.89，p=0.001]和个体血型：O 型 [AOR=8.93，95%CI：1.79-44.48，p=0.008]和 A 型 [AOR=5.53，95%CI：1.08-28.36，p=0.040]。性别、年龄、婚姻状况、职业、教育程度、居住地、吸烟以及咖啡、茶、水果和蔬菜的消费与 H. pylori 抗原检测无统计学关联（p>0.05）。
总体而言，H. pylori 粪便抗原和抗 H. pylori IgG 的检测率分别为 30.4%和 60.5%。检测一致性不具有很强的说服力，需要进一步评估。饮酒、过度拥挤和 ABO 血型与 H. pylori 抗原检测显著相关。
