Ress S R, Strassmann G, Bach F H
Scand J Immunol. 1985 Nov;22(5):455-61. doi: 10.1111/j.1365-3083.1985.tb01903.x.
A DR-null and DQ-null mutant lymphoblastoid cell line (LCL) was used to generate cytotoxic T cells (CTL) to investigate DR expression on CTL. Effector T cells generated in human allogeneic mixed lymphocyte culture (MLC) were separated on a fluorescence-activated cell sorter (FACS) into DR-positive and DR-negative subsets. The great majority of detectable cytolytic activity, anti-class I and anti-class II (presumably anti-DP) CTL, as well as natural killer (NK)-like activity, resided within the DR-positive population.
利用一种DR基因缺失和DQ基因缺失的突变淋巴母细胞系（LCL）来产生细胞毒性T细胞（CTL），以研究CTL上的DR表达情况。在人同种异体混合淋巴细胞培养（MLC）中产生的效应T细胞在荧光激活细胞分选仪（FACS）上被分离为DR阳性和DR阴性亚群。绝大多数可检测到的细胞溶解活性、抗I类和抗II类（推测为抗DP）CTL以及自然杀伤（NK）样活性都存在于DR阳性群体中。
