Luo Ping, Liu Hua-Zhong, Le Xiao-Yan, Du Hui, Kang Xin-Huang
College of Chemistry & Environment, Guangdong Ocean University, Zhanjiang, Guangdong Province, PR China.
Biochemistry Center, Guangdong Ocean University, Zhanjiang, Guangdong Province, PR China.
Pak J Pharm Sci. 2018 Jan;31(1):25-29.
The present study was conducted to investigate the preventive effects of squid ink polysaccharides (SIP) on the damage of sperm and reproduction induced by cyclophosphamide that is most commonly used for treating clinically cancers. Male Kunming mice exposed to cyclophosphamide were administered with SIP and were sacrificed to determine sperm parameters, testicular antioxidant ability and reproductive capacity. Data indicated that cyclophosphamide caused obvious changes in mice such as significant reduction (P<0.01) of glutathione reductase activity (GR), vitamin C (Vc) content and total antioxidant capacity (T-AOC) in the testes, as well as elevation (P<0.01) of abnormal rates of sperm and fetus, and a decrease in the total fetal count and average fetal count (P<0.01), were totally alleviated by SIP. From these findings it can be concluded that SIP decreases chemotherapeutic damage to sperm and reproduction in mice induced by cyclophosphamide.
本研究旨在探讨鱿鱼墨多糖（SIP）对临床上最常用于治疗癌症的环磷酰胺所致精子损伤和生殖损害的预防作用。将暴露于环磷酰胺的雄性昆明小鼠给予SIP，然后处死以测定精子参数、睾丸抗氧化能力和生殖能力。数据表明，环磷酰胺可引起小鼠明显变化，如睾丸中谷胱甘肽还原酶活性（GR）、维生素C（Vc）含量和总抗氧化能力（T-AOC）显著降低（P<0.01），以及精子和胎儿异常率升高（P<0.01），总胎儿数和平均胎儿数减少（P<0.01），而SIP可完全缓解这些变化。从这些发现可以得出结论，SIP可减少环磷酰胺诱导的小鼠化疗对精子和生殖的损害。
