Institute for Systems Genomics, University of Connecticut, Storrs, CT
Department of Molecular and Cell Biology, University of Connecticut, Storrs, CT.
J Cell Biol. 2018 Feb 5;217(2):441-443. doi: 10.1083/jcb.201712173. Epub 2018 Jan 18.
Accurate and synchronous replication timing between chromosome homologues is essential for maintaining chromosome stability, yet how this is achieved has remained a mystery. In this issue, Platt et al. (2018. https://doi.org/10.1083/jcb.201707082) identify antisense LINE (L1) transcripts within long noncoding RNAs as the critical factor in maintaining synchronous chromosome-wide replication timing.
准确且同步的染色体同源物复制时间对于维持染色体稳定性至关重要，但这是如何实现的仍然是个谜。在本期杂志中，Platt 等人（2018. https://doi.org/10.1083/jcb.201707082）发现长非编码 RNA 内的反义 LINE（L1）转录本是维持染色体全基因组同步复制时间的关键因素。
