长非编码 RNA 在肺癌中扩增重塑癌症通路。
Long noncoding RNA amplified in lung cancer rewires cancer pathways.
机构信息
Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT.
出版信息
J Cell Biol. 2020 Sep 7;219(9). doi: 10.1083/jcb.202007098.
Abstract
Athie et al. (2020. J. Cell Biol. https://doi.org/10.1083/jcb.201908078) identify ALAL-1, a lncRNA frequently amplified or overexpressed in lung cancer, as an oncogenic driver, capable of promoting the proliferation and altering the immunogenicity of lung cancer cells.
摘要
Athie 等人（2020. J. Cell Biol. https://doi.org/10.1083/jcb.201908078）鉴定出一种长链非编码 RNA（lncRNA）ALAL-1，其在肺癌中经常扩增或过表达，是一种致癌驱动基因，能够促进肺癌细胞的增殖并改变其免疫原性。
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