Jakubowski J A, Ardlie N G, Chesterman C N, McGready J F, Morgan F J
Thromb Res. 1985 Sep 15;39(6):725-32. doi: 10.1016/0049-3848(85)90256-7.
Platelet function and serum lipid studies were conducted on nine healthy male subjects before and two hours after three separate meals, two of which were rich in fat: saturated fat (SF) or polyunsaturated fat (PUF), and a third control meal which contained no fat. Platelet activity was assessed by determination of in vivo platelet aggregate formation, and plasma levels of the platelet specific proteins platelet factor 4 (PF4) and beta-thromboglobulin (beta-TG). Serum triglyceride levels increased significantly after both fat containing meals but were unaffected by the fat free meal. Serum cholesterol levels were not affected by any of the three meals. Platelet function tests could not detect any alteration of in vivo platelet activity in terms of platelet aggregate formation or plasma concentrations of PF4 and beta-TG. These results are at variance with previously published studies that used less specific assays of platelet activity and which suggested platelet activation shortly after meals rich in SF.
对9名健康男性受试者在三餐前以及三餐后两小时进行了血小板功能和血脂研究。这三餐分别为：两餐富含脂肪，其中一餐富含饱和脂肪（SF），另一餐富含多不饱和脂肪（PUF），第三餐为不含脂肪的对照餐。通过测定体内血小板聚集体形成以及血小板特异性蛋白血小板因子4（PF4）和β-血小板球蛋白（β-TG）的血浆水平来评估血小板活性。两顿含脂肪的餐后血清甘油三酯水平显著升高，但无脂肪餐对其无影响。血清胆固醇水平不受这三餐中任何一餐的影响。血小板功能测试在血小板聚集体形成或PF4和β-TG的血浆浓度方面未检测到体内血小板活性有任何改变。这些结果与先前发表的研究结果不同，先前的研究使用的血小板活性检测方法特异性较低，并表明富含SF的餐后不久血小板会被激活。
