• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

衰老和富含生育三烯酚的馏分对大鼠大脑精氨酸代谢的影响。

Effects of Aging and Tocotrienol-Rich Fraction Supplementation on Brain Arginine Metabolism in Rats.

机构信息

Faculty of Medicine, Universiti Teknologi MARA, Sungai Buloh Campus, Sungai Buloh, Malaysia.

Department of Biochemistry, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.

出版信息

Oxid Med Cell Longev. 2017;2017:6019796. doi: 10.1155/2017/6019796. Epub 2017 Nov 19.

DOI:10.1155/2017/6019796
PMID:29348790
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5733770/
Abstract

Accumulating evidence suggests that altered arginine metabolism is involved in the aging and neurodegenerative processes. This study sought to determine the effects of age and vitamin E supplementation in the form of tocotrienol-rich fraction (TRF) on brain arginine metabolism. Male Wistar rats at ages of 3 and 21 months were supplemented with TRF orally for 3 months prior to the dissection of tissue from five brain regions. The tissue concentrations of L-arginine and its nine downstream metabolites were quantified using high-performance liquid chromatography and liquid chromatography tandem mass spectrometry. We found age-related alterations in L-arginine metabolites in the chemical- and region-specific manners. Moreover, TRF supplementation reversed age-associated changes in arginine metabolites in the entorhinal cortex and cerebellum. Multiple regression analysis revealed a number of significant neurochemical-behavioral correlations, indicating the beneficial effects of TRF supplementation on memory and motor function.

摘要

越来越多的证据表明，精氨酸代谢的改变与衰老和神经退行性过程有关。本研究旨在确定年龄和维生素 E 补充（以生育三烯酚丰富部分（TRF）的形式）对大脑精氨酸代谢的影响。雄性 Wistar 大鼠在 3 个月和 21 个月时口服补充 TRF3 个月，然后从五个脑区解剖组织。使用高效液相色谱和液相色谱串联质谱法定量测定 L-精氨酸及其九种下游代谢物的组织浓度。我们发现 L-精氨酸代谢物在化学和区域特异性方面存在与年龄相关的改变。此外，TRF 补充逆转了额皮质和小脑内与年龄相关的精氨酸代谢物变化。多元回归分析显示了一些显著的神经化学-行为相关性，表明 TRF 补充对记忆和运动功能具有有益作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dba2/5733770/d725c0eb27b9/OMCL2017-6019796.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dba2/5733770/70d39b247f4f/OMCL2017-6019796.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dba2/5733770/c802b16659f5/OMCL2017-6019796.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dba2/5733770/07e11145d7f5/OMCL2017-6019796.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dba2/5733770/da4d332870b2/OMCL2017-6019796.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dba2/5733770/d725c0eb27b9/OMCL2017-6019796.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dba2/5733770/70d39b247f4f/OMCL2017-6019796.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dba2/5733770/c802b16659f5/OMCL2017-6019796.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dba2/5733770/07e11145d7f5/OMCL2017-6019796.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dba2/5733770/da4d332870b2/OMCL2017-6019796.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dba2/5733770/d725c0eb27b9/OMCL2017-6019796.005.jpg

相似文献

1
Effects of Aging and Tocotrienol-Rich Fraction Supplementation on Brain Arginine Metabolism in Rats.衰老和富含生育三烯酚的馏分对大鼠大脑精氨酸代谢的影响。
Oxid Med Cell Longev. 2017;2017:6019796. doi: 10.1155/2017/6019796. Epub 2017 Nov 19.
2
The effects of prenatal and early postnatal tocotrienol-rich fraction supplementation on cognitive function development in male offspring rats.产前及产后早期补充富含生育三烯酚的组分对雄性子代大鼠认知功能发育的影响
BMC Neurosci. 2013 Jul 31;14:77. doi: 10.1186/1471-2202-14-77.
3
Tocotrienol rich fraction reverses age-related deficits in spatial learning and memory in aged rats.富含生育三烯酚的组分可逆转老年大鼠与年龄相关的空间学习和记忆缺陷。
Lipids. 2014 Sep;49(9):855-69. doi: 10.1007/s11745-014-3919-2.
4
Ageing alters behavioural function and brain arginine metabolism in male Sprague-Dawley rats.衰老大鼠行为功能和大脑精氨酸代谢的改变。
Neuroscience. 2012 Dec 13;226:178-96. doi: 10.1016/j.neuroscience.2012.09.013. Epub 2012 Sep 16.
5
Tocotrienol rich fraction (TRF) supplementation protects against oxidative DNA damage and improves cognitive functions in Wistar rats.补充富含生育三烯酚的组分（TRF）可保护Wistar大鼠免受氧化性DNA损伤并改善其认知功能。
Clin Ter. 2011;162(2):93-8.
6
Nephroprotective action of tocotrienol-rich fraction (TRF) from palm oil against potassium dichromate (K 2 Cr 2 O 7)-induced acute renal injury in rats.棕榈油中生育三烯酚丰富部分（TRF）对重铬酸钾（K 2 Cr 2 O 7 ）诱导的大鼠急性肾损伤的肾保护作用。
Chem Biol Interact. 2010 Jul 30;186(2):228-38. doi: 10.1016/j.cbi.2010.04.025. Epub 2010 Apr 28.
7
Aging affects L-arginine and its metabolites in memory-associated brain structures at the tissue and synaptoneurosome levels.衰老是影响与记忆相关的大脑结构组织和突触神经小体水平的 L-精氨酸及其代谢物的因素之一。
Neuroscience. 2012 May 3;209:21-31. doi: 10.1016/j.neuroscience.2012.02.021. Epub 2012 Feb 21.
8
Inhibitory effects of palm tocotrienol-rich fraction supplementation on bilirubin-metabolizing enzymes in hyperbilirubinemic adult rats.富含γ-生育三烯酚的棕榈油组分补充剂对高胆红素血症成年大鼠胆红素代谢酶的抑制作用。
PLoS One. 2014 Feb 20;9(2):e89248. doi: 10.1371/journal.pone.0089248. eCollection 2014.
9
Effects of withdrawal from repeated phencyclidine administration on behavioural function and brain arginine metabolism in rats.反复给予苯环利定后戒断对大鼠行为功能和脑精氨酸代谢的影响。
Pharmacol Biochem Behav. 2017 Feb;153:45-59. doi: 10.1016/j.pbb.2016.12.006. Epub 2016 Dec 13.
10
Tocotrienols have a nephroprotective action against lipid-induced chronic renal dysfunction in rats.生育三烯酚对大鼠脂质诱导的慢性肾功能不全具有肾保护作用。
Ren Fail. 2015 Feb;37(1):136-43. doi: 10.3109/0886022X.2014.959433. Epub 2014 Sep 18.

引用本文的文献

1
Scoping Review: The Role of Tocotrienol-Rich Fraction as a Potent Neuroprotective Agent.综述：富含生育三烯酚的组分作为一种有效的神经保护剂的作用
Int J Mol Sci. 2025 Aug 8;26(16):7691. doi: 10.3390/ijms26167691.
2
Tocotrienol-rich fraction (TRF) protects against retinal cell apoptosis and preserves visual behavior in rats with streptozotocin-induced diabetic retinopathy.富含生育三烯酚的馏分 (TRF) 可防止链脲佐菌素诱导的糖尿病视网膜病变大鼠的视网膜细胞凋亡，并维持其视觉行为。
BMC Complement Med Ther. 2024 Aug 30;24(1):322. doi: 10.1186/s12906-024-04614-y.
3
Dysregulation of acyl carnitines, pentose phosphate pathway and arginine and ornithine metabolism are associated with decline in intrinsic capacity in Chinese older adults.

本文引用的文献

1
Tocotrienol rich fraction reverses age-related deficits in spatial learning and memory in aged rats.富含生育三烯酚的组分可逆转老年大鼠与年龄相关的空间学习和记忆缺陷。
Lipids. 2014 Sep;49(9):855-69. doi: 10.1007/s11745-014-3919-2.
2
Ascorbic acid and the brain: rationale for the use against cognitive decline.抗坏血酸与大脑：用于对抗认知能力下降的基本原理。
Nutrients. 2014 Apr 24;6(4):1752-81. doi: 10.3390/nu6041752.
3
Altered arginine metabolism in Alzheimer's disease brains.阿尔茨海默病大脑中精氨酸代谢的改变。
酰基辅酶 A、戊糖磷酸途径以及精氨酸和瓜氨酸代谢的失调与中国老年人内在能力下降有关。
Aging Clin Exp Res. 2024 Feb 12;36(1):36. doi: 10.1007/s40520-023-02654-x.
4
L-arginine metabolism ameliorates age-related cognitive impairment by Amuc_1100-mediated gut homeostasis maintaining.L-精氨酸代谢通过 Amuc_1100 介导的肠道稳态维持改善与年龄相关的认知障碍。
Aging Cell. 2024 Apr;23(4):e14081. doi: 10.1111/acel.14081. Epub 2024 Jan 18.
5
Tocotrienol-Rich Fraction and Levodopa Regulate Proteins Involved in Parkinson's Disease-Associated Pathways in Differentiated Neuroblastoma Cells: Insights from Quantitative Proteomic Analysis.富含生育三烯酚的馏分和左旋多巴调节分化神经母细胞瘤细胞中与帕金森病相关通路的蛋白质：定量蛋白质组学分析的见解。
Nutrients. 2022 Nov 3;14(21):4632. doi: 10.3390/nu14214632.
6
Modulation of Proteome Profile in AβPP/PS1 Mice Hippocampus, Medial Prefrontal Cortex, and Striatum by Palm Oil Derived Tocotrienol-Rich Fraction.富含生育三烯酚的棕榈油衍生馏分对 APP/PS1 小鼠海马体、内侧前额叶皮质和纹状体蛋白质组谱的调节作用。
J Alzheimers Dis. 2019;72(1):229-246. doi: 10.3233/JAD-181171.
7
Tocotrienol Rich Fraction Supplementation Modulate Brain Hippocampal Gene Expression in APPswe/PS1dE9 Alzheimer's Disease Mouse Model.生育三烯酚富集物补充剂可调节 APPswe/PS1dE9 阿尔茨海默病小鼠模型大脑海马的基因表达。
J Alzheimers Dis. 2019;70(s1):S239-S254. doi: 10.3233/JAD-180496.
Neurobiol Aging. 2014 Sep;35(9):1992-2003. doi: 10.1016/j.neurobiolaging.2014.03.013. Epub 2014 Mar 20.
4
Effect of vitamin E and memantine on functional decline in Alzheimer disease: the TEAM-AD VA cooperative randomized trial.维生素 E 和美金刚对阿尔茨海默病功能衰退的影响：TEAM-AD VA 合作随机试验。
JAMA. 2014 Jan 1;311(1):33-44. doi: 10.1001/jama.2013.282834.
5
Serum levels of vitamin E forms and risk of cognitive impairment in a Finnish cohort of older adults.血清中维生素 E 形态水平与芬兰老年人群认知障碍风险的关系。
Exp Gerontol. 2013 Dec;48(12):1428-35. doi: 10.1016/j.exger.2013.09.006. Epub 2013 Oct 7.
6
Neuroprotective effects of α-tocotrienol on kainic acid-induced neurotoxicity in organotypic hippocampal slice cultures.α-生育三烯酚对海人酸诱导的器官型海马脑片培养神经毒性的神经保护作用。
Int J Mol Sci. 2013 Sep 5;14(9):18256-68. doi: 10.3390/ijms140918256.
7
Regional variations and age-related changes in arginine metabolism in the rat brain stem and spinal cord.大鼠脑干和脊髓精氨酸代谢的区域变化和年龄相关性变化。
Neuroscience. 2013 Nov 12;252:98-108. doi: 10.1016/j.neuroscience.2013.08.002. Epub 2013 Aug 9.
8
Ageing alters behavioural function and brain arginine metabolism in male Sprague-Dawley rats.衰老大鼠行为功能和大脑精氨酸代谢的改变。
Neuroscience. 2012 Dec 13;226:178-96. doi: 10.1016/j.neuroscience.2012.09.013. Epub 2012 Sep 16.
9
Aging affects L-arginine and its metabolites in memory-associated brain structures at the tissue and synaptoneurosome levels.衰老是影响与记忆相关的大脑结构组织和突触神经小体水平的 L-精氨酸及其代谢物的因素之一。
Neuroscience. 2012 May 3;209:21-31. doi: 10.1016/j.neuroscience.2012.02.021. Epub 2012 Feb 21.
10
Tocopherols and tocotrienols plasma levels are associated with cognitive impairment.生育酚和三烯生育酚的血浆水平与认知障碍有关。
Neurobiol Aging. 2012 Oct;33(10):2282-90. doi: 10.1016/j.neurobiolaging.2011.11.019. Epub 2011 Dec 20.