Lin Yi, Jiang Xiao-Fang, Duan Xiangyan, Zeng Fang, Wu Bo, Wu Shuizhu
State Key Laboratory of Luminescent Materials and Devices, College of Materials Science and Engineering, South China University of Technology (SCUT), Guangzhou 510640, China.
ACS Med Chem Lett. 2017 Dec 22;9(1):23-27. doi: 10.1021/acsmedchemlett.7b00394. eCollection 2018 Jan 11.
Using light as the sole stimulus and employing the generated singlet oxygen as a therapeutic agent and the trigger to activate chemo-drug release could serve as an elegant way to bring into full play the advantageous features of light and enhance therapeutic efficacy through a combination of chemotherapy and photodynamic therapy. Herein a liposomal drug system has been developed by embedding a fluorescent photosensitizer and a prodrug into phospholipid vesicles. Upon one- or two-photon light irradiation, the photosensitizer generates singlet oxygen, which removes the protecting group of the prodrug and subsequently causes the release of the active drug chlorambucil. With the combined action of O and chlorambucil, highly controllable cytotoxicity toward cancer cells was achieved. In addition, the fluorescent photosensitizer gives out fluorescent signal acting as the drug monitoring agent. This strategy may provide an efficient approach for cancer treatment and some useful insights for designing light-stimulated on-demand therapeutic systems.
将光作为唯一刺激因素，利用产生的单线态氧作为治疗剂以及激活化疗药物释放的触发因素，可能是一种充分发挥光的优势特性并通过化疗与光动力疗法相结合来提高治疗效果的巧妙方法。在此，通过将荧光光敏剂和前药嵌入磷脂囊泡中，开发了一种脂质体药物系统。在单光子或双光子光照射下，光敏剂产生单线态氧，该单线态氧去除前药的保护基团，随后导致活性药物苯丁酸氮芥释放。在单线态氧和苯丁酸氮芥的共同作用下，实现了对癌细胞的高度可控细胞毒性。此外，荧光光敏剂发出荧光信号，作为药物监测剂。该策略可能为癌症治疗提供一种有效方法，并为设计光刺激按需治疗系统提供一些有用的见解。
