Estrada Michelle A, Zhao Xiao, Lorent Kristin, Kriegermeier Alyssa, Nagao Seika A, Berritt Simon, Wells Rebecca G, Pack Michael, Winkler Jeffrey D
Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.
Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.
ACS Med Chem Lett. 2017 Dec 14;9(1):61-64. doi: 10.1021/acsmedchemlett.7b00479. eCollection 2018 Jan 11.
We report the first synthesis of the plant isoflavonoid biliatresone. The convergent synthesis has been applied to the synthesis of several analogs, which have facilitated the first structure-activity relationship study for this environmental toxin that, on ingestion, recapitulates the phenotype of biliary atresia.
我们报道了植物异黄酮双氢愈创木薁的首次合成。这种汇聚式合成方法已应用于多种类似物的合成,这有助于首次对这种环境毒素进行构效关系研究,该毒素在摄入后会重现胆道闭锁的表型。