[Effect of the combined action of hydrogen fluoride and phosphine on the structural and functional properties of the sarcoplasmic reticulum membranes of the myocardium with nutrition of varying character].

A study was made of the activity of transport ATPases of rat myocardial sarcoplasmic reticulum membranes under the conditions of different-character nutrition and under the action of hydrogen fluoride and phosphine. The combined effect of the gases under study was accompanied by activation of Ca2+ ATPase and total ATPase. The character of nutrition, the degree of its adequacy according to retinol, tocopherol, ascorbic acid and essential amino acids (lysine, methionine, and threonine) determined not only the activity of transport ATPases and the phospholipid content of sarcoplasmic reticulum membranes but also the features of the toxic effects of hydrogen fluoride and phosphine. The enrichment of the diet with retinol, tocopherol, ascorbic acid and thiamine reduces the toxic effects of these gases under the conditions of acute and chronic priming as well.