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鼻眶脑毛霉菌病:糖尿病失控的致命并发症

Rhino-Orbital-Cerebral Mucormycosis: A Fatal Complication of Uncontrolled Diabetes Mellitus.

作者信息

Bavikar Purva, Mehta Varshil

机构信息

Department of Internal Medicine, MGM Medical College, Navi Mumbai, India.

出版信息

Cureus. 2017 Nov 13;9(11):e1841. doi: 10.7759/cureus.1841.

DOI:10.7759/cureus.1841
PMID:29348987
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5768320/
Abstract

Mucormycosis is a progressively invasive disease, with a fatal outcome, on late presentation. A 38-year-old female presented with diabetic ketoacidosis with right eye ptosis and a frozen globe without any signs of inflammation, externally. She underwent transnasal endoscopic debridement of paranasal sinuses and exenteration of the right eye. The histopathology specimen revealed the growth of mucormycosis. She was treated with intravenous (IV) amphotericin B, IV insulin, and extensive debridement surgery, but had an unfavorable outcome due to rapid mucor invasion to the brain.

摘要

毛霉菌病是一种进行性侵袭性疾病,若就诊延迟则预后不良。一名38岁女性因糖尿病酮症酸中毒就诊,伴有右眼上睑下垂和眼球固定,外观无任何炎症迹象。她接受了经鼻内镜鼻窦清创术和右眼眼球摘除术。组织病理学标本显示有毛霉菌生长。她接受了静脉注射两性霉素B、静脉注射胰岛素以及广泛的清创手术,但由于毛霉菌迅速侵袭脑部,预后不佳。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a479/5768320/b73751f548cf/cureus-0009-00000001841-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a479/5768320/0e7ac3cd45a7/cureus-0009-00000001841-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a479/5768320/38d02e98aacc/cureus-0009-00000001841-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a479/5768320/2db44ae7b138/cureus-0009-00000001841-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a479/5768320/b73751f548cf/cureus-0009-00000001841-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a479/5768320/0e7ac3cd45a7/cureus-0009-00000001841-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a479/5768320/38d02e98aacc/cureus-0009-00000001841-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a479/5768320/2db44ae7b138/cureus-0009-00000001841-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a479/5768320/b73751f548cf/cureus-0009-00000001841-i04.jpg

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本文引用的文献

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Mucormycosis in India: unique features.印度的毛霉病:独特特征
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Mucormycosis in renal transplant recipients: predictors and outcome.肾移植受者的毛霉菌病:预测因素与预后
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Diabetes more than retinopathy, it's effect on the anterior segment of eye.糖尿病不仅影响视网膜病变,还会影响眼球前段。
World J Clin Cases. 2023 Jun 6;11(16):3736-3749. doi: 10.12998/wjcc.v11.i16.3736.
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IDCases. 2022 Sep 6;30:e01615. doi: 10.1016/j.idcr.2022.e01615. eCollection 2022.
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