Department of Ophthalmology and Visual Science, Chiba University, Graduate School of Medicine, Chiba, Japan.
Biomed Res Int. 2017;2017:7879691. doi: 10.1155/2017/7879691. Epub 2017 Dec 4.
The purpose of this study was to determine the efficacy of one-year treatment of diabetic macular edema (DME) with intravitreal aflibercept (IVA) injections on a practical protocol. The medical records of 51 eyes of 43 patients who were diagnosed with DME and had received IVA treatments were reviewed. The best-corrected visual acuity (BCVA) and the central macular thickness (CMT) were measured at the baseline and at 1, 3, 6, and 12 months after the IVA. The mean number of IVA injections was 3.8 ± 2.4. The mean BCVA was significantly better and the CMT was thinner after the IVA at all follow-up times ( < 0.05). The BCVA was better in eyes with a serous retinal detachment (SRD) than without a SRD ( < 0.01). There was a significant correlation between the photoreceptor outer segment (PROS) length and BCVA at the baseline and at 12 months after the IVA ( < 0.05). A fewer number of IVA injections significantly improved the BCVA and the CMT in eyes with DME after one-year treatment. IVA was more effective in the SRD+ group than in the SRD- group. The PROS length may be a predictive marker for visual outcomes after one-year treatment with IVA for DME (IRB#2272).
本研究旨在确定在实际方案中，玻璃体内注射阿柏西普（IVA）治疗糖尿病性黄斑水肿（DME）一年的疗效。回顾了 43 名被诊断为 DME 并接受 IVA 治疗的 51 只眼的病历。在基线和 IVA 后 1、3、6 和 12 个月测量最佳矫正视力（BCVA）和中心黄斑厚度（CMT）。IVA 的平均注射次数为 3.8 ± 2.4。IVA 后所有随访时间的平均 BCVA 均显著提高，CMT 均变薄（<0.05）。伴有浆液性视网膜脱离（SRD）的眼的 BCVA 优于无 SRD 的眼（<0.01）。IVA 前后基线和 12 个月时的光感受器外节（PROS）长度与 BCVA 呈显著相关性（<0.05）。IVA 注射次数较少可显著改善 DME 眼的 BCVA 和 CMT。IVA 在 SRD+组比在 SRD-组更有效。PROS 长度可能是 IVA 治疗 DME 一年后视力结果的预测标志物（IRB#2272）。
