Wilson Tyler J, Blackledge Meghan S, Vigueira Patrick A
Department of Biology, High Point University, High Point, NC 27268, United States.
Department of Chemistry, High Point University, High Point, NC 27268, United States.
Heliyon. 2018 Jan 12;4(1):e00501. doi: 10.1016/j.heliyon.2017.e00501. eCollection 2018 Jan.
The rapid increase in bacterial resistance to antibiotics is a global healthcare crisis. Non-antibiotic pharmaceuticals that have attained approval by the United States Food and Drug Administration have the potential to be repurposed as bacterial resistance-modifying agents and therefore could become valuable resources in our battle against antibiotic-resistant microbes. Amoxapine is a tetracyclic antidepressant used in the treatment of major depressive disorder. Here we demonstrate the ability of amoxapine to resensitize methicillin-resistant strain ATCC 43300 to oxacillin in both agar diffusion and broth microdilution assays. Amoxapine also reduced the bacterial cleavage of nitrocefin in a dose-dependent manner, suggesting that it may exert its adjuvant effects through reduction of beta-lactamase activity.
细菌对抗生素耐药性的迅速增加是一场全球医疗危机。已获得美国食品药品监督管理局批准的非抗生素药物有潜力被重新用作细菌耐药性调节剂，因此可能成为我们对抗抗生素耐药微生物斗争中的宝贵资源。阿莫沙平是一种用于治疗重度抑郁症的四环类抗抑郁药。在此，我们在琼脂扩散试验和肉汤微量稀释试验中均证明了阿莫沙平能使耐甲氧西林菌株ATCC 43300对苯唑西林重新敏感。阿莫沙平还以剂量依赖的方式减少了头孢硝噻吩的细菌裂解，这表明它可能通过降低β-内酰胺酶活性发挥其佐剂作用。
