Department of Medicine, University of Toronto, Toronto, ON, Canada.
Nontuberculous Mycobacteria Program, Department of Respirology, Toronto Western Hospital, University Health Network, Toronto, ON, Canada.
Lung. 2018 Apr;196(2):213-217. doi: 10.1007/s00408-018-0087-9. Epub 2018 Jan 18.
Mycobacterium xenopi is responsible for pulmonary disease (PD) in Europe and Canada. Despite its high prevalence and increasing clinical importance, little is known about the genetic diversity of M. xenopi. Through a prospective study for M. xenopi strain type and the relation to clinical phenotype, 39 patients with M. xenopi PD were analyzed. Our study demonstrated that sequence type (ST) 5 was dominant in Ontario among 15 distinct STs and caused PD in people even without underlying lung disease, whereas disease due to non-ST5 was found almost exclusively in patients with underlying lung disease.
耻垢分枝杆菌可引起欧洲和加拿大的肺部疾病（PD）。尽管其发病率高且临床重要性日益增加，但人们对耻垢分枝杆菌的遗传多样性知之甚少。通过对耻垢分枝杆菌菌株类型及其与临床表型的关系进行前瞻性研究，对 39 例耻垢分枝杆菌 PD 患者进行了分析。本研究表明，在安大略省的 15 个不同 ST 中，ST5 占优势，并且即使在没有潜在肺部疾病的人群中，也会引起 PD，而非 ST5 引起的疾病几乎仅见于有潜在肺部疾病的患者。
