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小脑:从发育到疾病——第八届国际小脑与共济失调研究学会研讨会

Cerebellum: from Development to Disease-the 8th International Symposium of the Society for Research on the Cerebellum and Ataxias.

作者信息

Marzban Hassan, Manto Mario, Mariani Jean

机构信息

Department of Human Anatomy and Cell Science, The Children's Hospital Research Institute of Manitoba (CHRIM), Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Rm 129 BMSB, 745 Bannatyne Avenue, Winnipeg, MB, R3E 0J9, Canada.

Unité d'Etude du Mouvement (UEM), FNRS, ULB-Erasme, 808 Route de Lennik, 1070, Brussels, Belgium.

出版信息

Cerebellum. 2018 Feb;17(1):1-3. doi: 10.1007/s12311-018-0919-4.

DOI:10.1007/s12311-018-0919-4
PMID:29349629
Abstract

In recent years, there has been tremendous growth in research on cerebellar motor and non-motor functions. Cerebellum is particularly involved in the spectrum of neurodevelopmental diseases. The 8th International Symposium of the Society for Research on the Cerebellum and Ataxia (SRCA) was held in Winnipeg, Manitoba, (Canada) on May 24-26, 2017. The main theme of the 8th International Symposium was "Development of the Cerebellum and Neurodevelopmental Disorders." Advances in genetics, epigenetic, cerebellar neurogenesis, axonogenesis and gliogenesis, cerebellar developmental disorders including autism spectrum disorders (ASD), neuroimaging, cerebellar ataxias, medulloblastoma, and clinical investigation of cerebellar diseases were presented. The goal of this symposium was to provide a platform to discuss cutting-edge knowledge while allowing researchers and trainees the opportunity to share and discuss their front-line research and ideas with others in the field, make connections, and strengthen international collaborations. The Ferdinando Rossi lecture was delivered by Dr. Richard Hawkes on the topic of patterning of the cerebellar cortex. This symposium emphasized the major importance of the involvement of the cerebellum in neurodevelopmental diseases from the clinical, radiological, biological, and genetic standpoint.

摘要

近年来,关于小脑运动和非运动功能的研究有了巨大的发展。小脑尤其与一系列神经发育疾病有关。第八届小脑与共济失调研究协会(SRCA)国际研讨会于2017年5月24日至26日在加拿大马尼托巴省温尼伯市举行。第八届国际研讨会的主题是“小脑发育与神经发育障碍”。会议展示了遗传学、表观遗传学、小脑神经发生、轴突发生和胶质发生方面的进展,包括自闭症谱系障碍(ASD)在内的小脑发育障碍、神经影像学、小脑共济失调、髓母细胞瘤以及小脑疾病的临床研究。本次研讨会的目标是提供一个平台,以讨论前沿知识,同时让研究人员和学员有机会与该领域的其他人员分享和讨论他们的前沿研究及想法,建立联系并加强国际合作。费迪南多·罗西讲座由理查德·霍克斯博士主讲,主题是小脑皮质的模式形成。本次研讨会从临床、放射学、生物学和遗传学角度强调了小脑在神经发育疾病中的重要作用。

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本文引用的文献

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Targeting the CACNA1A IRES as a Treatment for Spinocerebellar Ataxia Type 6.以 CACNA1A IRES 为靶点治疗脊髓小脑性共济失调 6 型。
Cerebellum. 2018 Feb;17(1):72-77. doi: 10.1007/s12311-018-0917-6.
2
Crus I in the Rodent Cerebellum: Its Homology to Crus I and II in the Primate Cerebellum and Its Anatomical Uniqueness Among Neighboring Lobules.鼠类小脑的 Crus I:与灵长类小脑 Crus I 和 II 的同源性,以及在相邻脑叶中的解剖独特性。
Cerebellum. 2018 Feb;17(1):49-55. doi: 10.1007/s12311-017-0911-4.
3
The Molecular Pathway Regulating Bergmann Glia and Folia Generation in the Cerebellum.
调控小脑 Bergmann 胶质细胞和叶片发生的分子途径。
Cerebellum. 2018 Feb;17(1):42-48. doi: 10.1007/s12311-017-0904-3.
4
Self-Organized Cerebellar Tissue from Human Pluripotent Stem Cells and Disease Modeling with Patient-Derived iPSCs.人多能干细胞来源的自发组织小脑组织和患者来源 iPSC 的疾病建模。
Cerebellum. 2018 Feb;17(1):37-41. doi: 10.1007/s12311-017-0905-2.
5
Epigenetic Drivers in Pediatric Medulloblastoma.小儿髓母细胞瘤的表观遗传学驱动因素。
Cerebellum. 2018 Feb;17(1):28-36. doi: 10.1007/s12311-017-0899-9.
6
Migration of Interneuron Precursors in the Nascent Cerebellar Cortex.神经前体细胞在初生小脑皮层中的迁移。
Cerebellum. 2018 Feb;17(1):62-71. doi: 10.1007/s12311-017-0900-7.
7
Protein Kinase C in the Cerebellum: Its Significance and Remaining Conundrums.小脑蛋白激酶 C:其意义与未解之谜。
Cerebellum. 2018 Feb;17(1):23-27. doi: 10.1007/s12311-017-0898-x.
8
The Ferdinando Rossi Memorial Lecture: Zones and Stripes-Pattern Formation in the Cerebellum.费迪南多·罗西纪念讲座:小脑的区域和条纹模式形成。
Cerebellum. 2018 Feb;17(1):12-16. doi: 10.1007/s12311-017-0887-0.
9
Presynaptic Mechanisms Mediating Retrograde Semaphorin Signals for Climbing Fiber Synapse Elimination During Postnatal Cerebellar Development.介导发育性小脑内攀附纤维突触消除的逆行信号素信号的突触前机制。
Cerebellum. 2018 Feb;17(1):17-22. doi: 10.1007/s12311-017-0888-z.
10
Climbing Fiber Development Is Impaired in Postnatal Car8 Mice.在出生后 Car8 敲除小鼠中, climbing fiber 发育受损。
Cerebellum. 2018 Feb;17(1):56-61. doi: 10.1007/s12311-017-0886-1.