化疗期间同时进行抗阻运动和高强度间歇训练产生的良好生理反应：OptiTrain 乳腺癌试验。

Highly favorable physiological responses to concurrent resistance and high-intensity interval training during chemotherapy: the OptiTrain breast cancer trial.

机构信息

Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.

Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.

出版信息

Breast Cancer Res Treat. 2018 May;169(1):93-103. doi: 10.1007/s10549-018-4663-8. Epub 2018 Jan 18.

DOI:10.1007/s10549-018-4663-8

PMID:29349712

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5882634/

Abstract

BACKGROUND

Advanced therapeutic strategies are often accompanied by significant adverse effects, which warrant equally progressive countermeasures. Physical exercise has proven an effective intervention to improve physical function and reduce fatigue in patients undergoing chemotherapy. Effects of high-intensity interval training (HIIT) in this population are not well established although HIIT has proven effective in other clinical populations. The aim of the OptiTrain trial was to examine the effects of concurrent resistance and high-intensity interval training (RT-HIIT) or concurrent moderate-intensity aerobic and high-intensity interval training (AT-HIIT), to usual care (UC) on pain sensitivity and physiological outcomes in patients with breast cancer during chemotherapy.

METHODS

Two hundred and forty women were randomized to 16 weeks of RT-HIIT, AT-HIIT, or UC.

OUTCOMES

cardiorespiratory fitness, muscle strength, body mass, hemoglobin levels, and pressure-pain threshold.

RESULTS

Pre- to post-intervention, RT-HIIT (ES = 0.41) and AT-HIIT (ES = 0.42) prevented the reduced cardiorespiratory fitness found with UC. Handgrip strength (surgery side: RT-HIIT vs. UC: ES = 0.41, RT-HIIT vs. AT-HIIT: ES = 0.28; non-surgery side: RT-HIIT vs. UC: ES = 0.35, RT-HIIT vs. AT-HIIT: ES = 0.22) and lower-limb muscle strength (RT-HIIT vs. UC: ES = 0.66, RT-HIIT vs. AT-HIIT: ES = 0.23) were significantly improved in the RT-HIIT. Increases in body mass were smaller in RT-HIIT (ES = - 0.16) and AT-HIIT (ES = - 0.16) versus UC. RT-HIIT reported higher pressure-pain thresholds than UC (trapezius: ES = 0.46, gluteus: ES = 0.53) and AT-HIIT (trapezius: ES = 0.30).

CONCLUSION

Sixteen weeks of RT-HIIT significantly improved muscle strength and reduced pain sensitivity. Both exercise programs were well tolerated and were equally efficient in preventing increases in body mass and in preventing declines in cardiorespiratory fitness. These results highlight the importance of implementing a combination of resistance and high-intensity interval training during chemotherapy for women with breast cancer.

摘要

背景

先进的治疗策略通常伴随着显著的不良反应，这需要同样先进的对策。运动已被证明是一种有效干预措施，可以改善化疗患者的身体功能并减轻疲劳。高强度间歇训练（HIIT）在该人群中的效果尚不清楚，尽管 HIIT 已被证明对其他临床人群有效。OptiTrain 试验的目的是研究在乳腺癌患者化疗期间，同时进行阻力和高强度间歇训练（RT-HIIT）或同时进行中等强度有氧运动和高强度间歇训练（AT-HIIT）与常规护理（UC）相比，对疼痛敏感性和生理结果的影响。

方法

240 名女性被随机分为 16 周的 RT-HIIT、AT-HIIT 或 UC。

结果

心肺功能、肌肉力量、体重、血红蛋白水平和压痛阈值。

结果

与 UC 相比，RT-HIIT（ES=0.41）和 AT-HIIT（ES=0.42）可预防心肺功能下降。握力（手术侧：RT-HIIT 与 UC：ES=0.41，RT-HIIT 与 AT-HIIT：ES=0.28；非手术侧：RT-HIIT 与 UC：ES=0.35，RT-HIIT 与 AT-HIIT：ES=0.22）和下肢肌肉力量（RT-HIIT 与 UC：ES=0.66，RT-HIIT 与 AT-HIIT：ES=0.23）在 RT-HIIT 中得到显著改善。与 UC 相比，RT-HIIT（ES=-0.16）和 AT-HIIT（ES=-0.16）的体重增加较小。与 UC 相比，RT-HIIT 报告的压痛阈值更高（斜方肌：ES=0.46，臀肌：ES=0.53）和 AT-HIIT（斜方肌：ES=0.30）。