Downs Tahnee L, Whiteside Eliza J, Denham Joshua, Mills Dean E, Bliss Edward S
School of Health and Medical Sciences, University of Southern Queensland, Toowoomba, QLD 4350, Australia.
Respiratory and Exercise Physiology Research Group, University of Southern Queensland, Ipswich, QLD 4305, Australia.
J Clin Med. 2024 Dec 22;13(24):7841. doi: 10.3390/jcm13247841.
Breast cancer is the most diagnosed cancer globally. While the breast cancer prevalence continues to rise, so too do patient survival rates, thus resulting in a large survivor population. Up to 75% of this population report experiencing cancer-related cognitive impairment during their cancer journey, thus reducing their quality of survivorship. This review systematically evaluates the effect of physical activity and exercise training on cerebrovascular function and cognition in breast cancer survivors. Cross-sectional, intervention or observational studies that examined the effect of acute or chronic exercise training or physical activity levels on cerebrovascular function and cognition in female breast cancer survivors were searched for systematically. The 11 included studies were tabulated and described narratively. The included studies primarily focused on aerobic exercise training, while only four studies investigated the effect of resistance exercise training or concurrent training on cerebrovascular function and/or cognition in breast cancer survivors. Collectively, these studies provide preliminary evidence supporting the positive effect of exercise training on cerebrovascular function and cognition in breast cancer survivors, irrespective of their age, stage of breast cancer and treatment regimen. However, more research is required to comprehensively evaluate the effect of exercise training on cerebrovascular function and cognition in breast cancer survivors and the mechanisms leading to these potential improvements.
乳腺癌是全球诊断出的最常见癌症。尽管乳腺癌的患病率持续上升，但患者的生存率也在提高，从而导致了大量的幸存者群体。该群体中高达75%的人报告在患癌过程中经历了与癌症相关的认知障碍，进而降低了他们的生存质量。本综述系统地评估了体育活动和运动训练对乳腺癌幸存者脑血管功能和认知的影响。系统检索了横断面研究、干预研究或观察性研究，这些研究探讨了急性或慢性运动训练或身体活动水平对女性乳腺癌幸存者脑血管功能和认知的影响。对纳入的11项研究进行了列表并进行了叙述性描述。纳入的研究主要集中在有氧运动训练，而只有四项研究调查了抗阻运动训练或联合训练对乳腺癌幸存者脑血管功能和/或认知的影响。总体而言，这些研究提供了初步证据，支持运动训练对乳腺癌幸存者脑血管功能和认知具有积极影响，无论其年龄、乳腺癌分期和治疗方案如何。然而，需要更多的研究来全面评估运动训练对乳腺癌幸存者脑血管功能和认知的影响以及导致这些潜在改善的机制。
