Rinaldo J E, Pennock B
Am J Med Sci. 1986 Jan;291(1):29-38. doi: 10.1097/00000441-198601000-00007.
Ibuprofen is a cyclo-oxygenase inhibitor that is alleged to have additional direct effects on leukocyte function. These properties suggest that Ibuprofen may be of potential therapeutic value for neutrophil (PMN)-mediated acute lung injury in humans such as that resulting from septicemia by gram-negative organisms. This study quantitated the effect of pretreatment with Ibuprofen on the intensity of acute neutrophilic alveolitis following endotoxemia. The effect of Ibuprofen on neutrophilic alveolitis was biphasic: There was suppression of inflammation at a high dose (30 mg/kg), enhancement at a low dose (3 mg/kg), and intermediate doses (10-20 mg/kg) had no effect. In contrast, both 10 and 30 mg/kg of Ibuprofen prevented early hypoxemia following endotoxemia, suggesting that early hypoxemia and inflammation by neutrophils were not causally related. The dose of Ibuprofen required to suppress neutrophil alveolitis exceeds that required to inhibit cyclooxygenase in the model. Therefore, suppression of alveolitis by 30 mg/kg of Ibuprofen may depend on other pharmacologic properties of Ibuprofen such as its direct effect on neutrophil migration.
布洛芬是一种环氧化酶抑制剂，据称对白细胞功能还有其他直接作用。这些特性表明，布洛芬可能对人类中性粒细胞（PMN）介导的急性肺损伤具有潜在治疗价值，比如由革兰氏阴性菌败血症导致的急性肺损伤。本研究定量分析了布洛芬预处理对内毒素血症后急性嗜中性肺泡炎强度的影响。布洛芬对嗜中性肺泡炎的影响呈双相性：高剂量（30毫克/千克）时炎症受到抑制，低剂量（3毫克/千克）时炎症增强，中等剂量（10 - 20毫克/千克）则无影响。相比之下，10毫克/千克和30毫克/千克的布洛芬均可预防内毒素血症后的早期低氧血症，这表明早期低氧血症与中性粒细胞炎症并无因果关系。在该模型中，抑制嗜中性肺泡炎所需的布洛芬剂量超过了抑制环氧化酶所需的剂量。因此，30毫克/千克的布洛芬对肺泡炎的抑制作用可能取决于布洛芬的其他药理特性，比如其对中性粒细胞迁移的直接作用。
