Izgi Murat, Basaran Betul, Muderrisoglu Ahmet, Ankay Yilbas Aysun, Uluer Mehmet S, Celebioglu Bilge
Department of Anesthesiology and Reanimation, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
Department of Anesthesiology and Reanimation, Konya Training and Research Hospital, Konya, Turkey.
Paediatr Anaesth. 2018 Mar;28(3):275-280. doi: 10.1111/pan.13318. Epub 2018 Jan 19.
The combination of propofol and ketamine is commonly used for total intravenous anesthesia. These drugs can be delivered in different syringes or in the same syringe. We hypothesized that the drugs might separate and different concentrations of each drug could be found in different parts of the syringe during the procedure period when they were mixed in 1 syringe.
Twelve 60-mL polypropylene syringes were prepared by mixing propofol and ketamine as 4 groups on the basis of propofol/ketamine mixture ratios (5:1 and 6.7:1) and propofol solution concentrations. Syringes were placed upright in the vertical position into a rack and kept at room temperature (21.5-22.5°C), in daylight conditions and were not moved for 360 minutes. Samples of the mixture were taken from both the top and the bottom of the syringe. The first 1 mL of the samples was discarded, the following second 1 mL of the samples was filtered using 0.2-μm polytetrafluoroethylene filters and measured twice (n = 6). Samples were taken at the following time intervals: T0, T10, T30, T60, T90, T120, T180, T240, T300, and T360 min. Syringes were checked visually for any color change and separation lines between the drugs.
There were no significant differences between the propofol and ketamine concentrations of the top and bottom samples in all 4 groups. In addition, there were no statistically significant changes of propofol and ketamine concentrations of samples over 360 minutes in any of the 4 groups. No visual changes were observed during 6 hours' observation.
The results of our measurements demonstrated that mixtures of propofol (1% and 2%) and ketamine at 5:1 and 6.7:1 ratios could be used in terms of mixture homogeneity and stability in a polypropylene syringe during a 6-hour period at room temperature.
丙泊酚和氯胺酮联合常用于全静脉麻醉。这些药物可以用不同的注射器给药，也可以混合在同一个注射器中。我们推测，当它们混合在一个注射器中时，在操作过程中药物可能会分离，并且在注射器的不同部位会发现每种药物的不同浓度。
根据丙泊酚/氯胺酮混合比例（5:1和6.7:1）以及丙泊酚溶液浓度，将丙泊酚和氯胺酮混合制备12个60毫升聚丙烯注射器，分为4组。将注射器垂直放置在架子上，保持在室温（21.5 - 22.5°C）、日光条件下，360分钟内不移动。从注射器顶部和底部采集混合物样本。样本的前1毫升弃去，接下来的第2个1毫升样本用0.2微米聚四氟乙烯过滤器过滤并测量两次（n = 6）。在以下时间间隔采集样本：T0、T10、T30、T60、T90、T120、T180、T240、T300和T360分钟。目视检查注射器，观察药物之间是否有颜色变化和分界线。
所有4组顶部和底部样本的丙泊酚和氯胺酮浓度之间无显著差异。此外，4组中任何一组在360分钟内样本的丙泊酚和氯胺酮浓度均无统计学显著变化。在6小时观察期间未观察到目视变化。
我们的测量结果表明，在室温下6小时内，聚丙烯注射器中丙泊酚（1%和2%）与氯胺酮按5:1和6.7:1比例混合的混合物在混合均匀性和稳定性方面是可用的。
