From the Defense and Veterans Center for Integrative Pain Management, Henry M. Jackson Foundation, Rockville, Maryland.
Uniformed Services University, Bethesda, Maryland.
Anesth Analg. 2019 Jul;129(1):e13-e15. doi: 10.1213/ANE.0000000000003772.
Admixtures of propofol-ketamine, propofol-ketamine-fentanyl, and propofol-ketamine-remifentanil were subjected to various clinically relevant conditions to study their chemical stability. A novel high-performance liquid chromatography-mass spectrometry method revealed no degradation of any compound by incubation at 37°C, constant mixing, or table-top storage for 6- and 24-hour time periods, except variable recovery of both propofol and fentanyl in the admixtures of propofol-ketamine-fentanyl suggesting possible degradation.
将丙泊酚-氯胺酮、丙泊酚-氯胺酮-芬太尼和丙泊酚-氯胺酮-瑞芬太尼混合物置于各种临床相关条件下进行研究，以考察其化学稳定性。一项新的高效液相色谱-质谱法研究表明，在 37°C 孵育、持续混合或桌面储存 6 小时和 24 小时的条件下，没有任何化合物发生降解，除了丙泊酚-氯胺酮-芬太尼混合物中丙泊酚和芬太尼的回收率不同，提示可能发生了降解。
