Department of Obstetrics and Gynecology, Yonsei University College of Medicine, Seoul, Korea.
Institute of Women's Life Medical Science, Yonsei University Health System, Seoul, Korea.
J Korean Med Sci. 2018 Feb 5;33(6):e35. doi: 10.3346/jkms.2018.33.e35.
Multiple studies have been reported regarding preeclampsia as a possible risk factor of cerebrovascular disease (CVD). However, the correlation of preeclampsia and CVD, whether it is a cause-effect relationship or they are sharing common predisposing condition, is not well understood. Therefore, the aim of this study was to investigate the association between the preeclampsia during pregnancy and development of postpartum CVD.
A total of 1,384,550 Korean women who had a delivery between January 1, 2010 and December 31, 2012, were enrolled. Women with the risk of CVD within 1 year prior to pregnancy were excluded based on the Charlson comorbidity index. Primary endpoint was the event of CVD within a year from delivery. After exclusion, 1,075,061 women were analyzed.
During the follow-up of 1 year postpartum, there were 25,577 preeclampsia out of 1,072,041 women without postpartum CVD (2.39%), and 121 of 3,020 women with postpartum CVD had preeclampsia before delivery (4.01%). In multivariate logistic regression analysis, women who had preeclampsia during pregnancy showed a higher risk for postpartum CVD (odds ratio, 1.64; 95% confidence interval, 1.37-1.98).
The incidence of CVD after delivery was higher in women who had preeclampsia during pregnancy.
已有多项研究报道子痫前期是脑血管疾病（CVD）的一个可能危险因素。然而，子痫前期与 CVD 的相关性，无论是因果关系还是它们共享共同的易患条件，都还没有被很好地理解。因此，本研究旨在探讨妊娠期间子痫前期与产后 CVD 发生的关系。
共纳入 2010 年 1 月 1 日至 2012 年 12 月 31 日分娩的 1384550 名韩国女性。根据 Charlson 合并症指数，排除妊娠前 1 年内有 CVD 风险的女性。主要终点是产后 1 年内 CVD 的发生。排除后，共分析了 1075061 名女性。
在产后 1 年的随访中，在没有产后 CVD 的 1072041 名女性中，有 25577 名（2.39%）患有子痫前期，而在 3020 名患有产后 CVD 的女性中，有 121 名（4.01%）在分娩前患有子痫前期。在多变量逻辑回归分析中，患有妊娠子痫前期的女性产后发生 CVD 的风险更高（优势比，1.64；95%置信区间，1.37-1.98）。
患有妊娠子痫前期的女性产后 CVD 的发生率更高。
