硫叶立德在芳基炔烃的 1,2-双官能化反应中通过插入 C-S σ 键的应用。
Application of Sulfur Ylides in 1,2-Difunctionalization of Arynes via Insertion into a C-S σ-Bond.
机构信息
Division of Organic Chemistry and ‡Academy of Scientific and Innovative Research (AcSIR), CSIR-National Chemical Laboratory , Pune 411008, India.
出版信息
Org Lett. 2018 Feb 2;20(3):848-851. doi: 10.1021/acs.orglett.7b04003. Epub 2018 Jan 19.
PMID:29350042
Abstract
A novel reactivity of sulfur ylides has been demonstrated in a transition-metal-free protocol to access ortho-substituted thioanisole derivatives by insertion of arynes into a C-S σ-bond in moderate to good yields. The reaction involves the formation of C-C and C-S bonds and consecutive breaking of two C-S bonds under operationally mild reaction conditions.
摘要
一种新型的硫叶立德反应活性已经在一个无过渡金属的协议中得到证明，该协议通过芳炔插入 C-S σ 键，以中等至良好的收率获得邻位取代的硫代苯甲醚衍生物。该反应涉及 C-C 和 C-S 键的形成，以及在操作温和的反应条件下连续断裂两个 C-S 键。
Zotero 插件