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IRF2BP2-RARA t(1;17)(q42.3;q21.2) APL blasts differentiate in response to all-trans retinoic acid.

作者信息

Mazharuddin Samir, Chattopadhyay Anuja, Levy Moshe Y, Redner Robert L

机构信息

a Baylor University Medical Center , Dallas , TX , USA.

b UPMC Hillman Cancer Center and University of Pittsburgh , Pittsburgh , PA , USA.

出版信息

Leuk Lymphoma. 2018 Sep;59(9):2246-2249. doi: 10.1080/10428194.2017.1421761. Epub 2018 Jan 19.

DOI:10.1080/10428194.2017.1421761
PMID:29350080
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6162987/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa37/6162987/8fa75333d7ae/nihms-1504720-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa37/6162987/12780c99b338/nihms-1504720-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa37/6162987/e0155715e29a/nihms-1504720-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa37/6162987/121a4f8f2d7e/nihms-1504720-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa37/6162987/8fa75333d7ae/nihms-1504720-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa37/6162987/12780c99b338/nihms-1504720-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa37/6162987/e0155715e29a/nihms-1504720-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa37/6162987/121a4f8f2d7e/nihms-1504720-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa37/6162987/8fa75333d7ae/nihms-1504720-f0004.jpg

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本文引用的文献

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The cryptic IRF2BP2-RARA fusion transforms hematopoietic stem/progenitor cells and induces retinoid-sensitive acute promyelocytic leukemia.隐匿性IRF2BP2-RARA融合基因可转化造血干/祖细胞并引发对维甲酸敏感的急性早幼粒细胞白血病。
Leukemia. 2017 Mar;31(3):747-751. doi: 10.1038/leu.2016.338. Epub 2016 Nov 22.
2
New variant of acute promyelocytic leukemia with IRF2BP2-RARA fusion.伴有IRF2BP2-RARA融合的急性早幼粒细胞白血病新变体。
Cancer Sci. 2016 Aug;107(8):1165-8. doi: 10.1111/cas.12970.
3
Identification of a novel fusion gene, IRF2BP2-RARA, in acute promyelocytic leukemia.在急性早幼粒细胞白血病中鉴定出一种新型融合基因IRF2BP2-RARA。
J Natl Compr Canc Netw. 2015 Jan;13(1):19-22. doi: 10.6004/jnccn.2015.0005.
4
GTF2I-RARA is a novel fusion transcript in a t(7;17) variant of acute promyelocytic leukaemia with clinical resistance to retinoic acid.GTF2I-RARA是急性早幼粒细胞白血病t(7;17)变异型中的一种新型融合转录本，对维甲酸具有临床耐药性。
Br J Haematol. 2015 Mar;168(6):904-8. doi: 10.1111/bjh.13157. Epub 2014 Oct 4.
5
TBLR1 fuses to retinoid acid receptor α in a variant t(3;17)(q26;q21) translocation of acute promyelocytic leukemia.TBLR1 与维甲酸受体 α 在急性早幼粒细胞白血病的变异 t(3;17)(q26;q21)易位中融合。
Blood. 2014 Aug 7;124(6):936-45. doi: 10.1182/blood-2013-10-528596. Epub 2014 Apr 29.
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OBFC2A/RARA: a novel fusion gene in variant acute promyelocytic leukemia.OBFC2A/RARA：变异型急性早幼粒细胞白血病的一个新融合基因。
Blood. 2013 Feb 21;121(8):1432-5. doi: 10.1182/blood-2012-04-423129. Epub 2013 Jan 3.
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Interferon regulatory factor 2 binding protein 2 is a new NFAT1 partner and represses its transcriptional activity.干扰素调节因子 2 结合蛋白 2 是 NFAT1 的新伴侣，并抑制其转录活性。
Mol Cell Biol. 2011 Jul;31(14):2889-901. doi: 10.1128/MCB.00974-10. Epub 2011 May 16.
8
BCOR as a novel fusion partner of retinoic acid receptor alpha in a t(X;17)(p11;q12) variant of acute promyelocytic leukemia.BCOR 作为急性早幼粒细胞白血病 t(X;17)(p11;q12)变异型中 retinoic acid receptor alpha 的新型融合伙伴。
Blood. 2010 Nov 18;116(20):4274-83. doi: 10.1182/blood-2010-01-264432. Epub 2010 Aug 31.
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The seventh pathogenic fusion gene FIP1L1-RARA was isolated from a t(4;17)-positive acute promyelocytic leukemia.第七种致病性融合基因FIP1L1-RARA是从t(4;17)阳性急性早幼粒细胞白血病中分离出来的。
Haematologica. 2008 Sep;93(9):1414-6. doi: 10.3324/haematol.12854. Epub 2008 Jul 4.
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The PRKAR1A gene is fused to RARA in a new variant acute promyelocytic leukemia.在一种新的变异型急性早幼粒细胞白血病中，PRKAR1A基因与RARA融合。
Blood. 2007 Dec 1;110(12):4073-6. doi: 10.1182/blood-2007-06-095554. Epub 2007 Aug 21.