a Hypertension in Africa Research Team (HART), North-West University, Potchefstroom Campus , Potchefstroom , South Africa.
b MRC Research Unit for Hypertension and Cardiovascular Disease, North-West University , Potchefstroom , South Africa.
Free Radic Res. 2018 Feb;52(2):180-187. doi: 10.1080/10715762.2017.1421314. Epub 2018 Jan 19.
Early cardiovascular disease (CVD) onset can be inflicted by familial cardiovascular and lifestyle risk factors. We aimed to compare phenotypic characteristics and explore associations between oxidative stress and vascular function in boys stratified by maternal cardiovascular and lifestyle risk. We included 40 Black and 41 White boys (ages 6-8 years), along with the biological mother of each child. The study population was divided into two groups (nonmaternal risk vs. maternal risk) according to maternal risk predetermined by their selfreported cardiovascular and lifestyle risk factors. Pulse wave velocity (PWV) was measured at various sites and blood pressures were recorded. Urine samples were collected for analyses of thiobarbituric acid-reactive substances (TBARS), 8-hydroxy-2-deoxy guanosine (8-OHdG), albumin, and creatinine. Higher levels of urinary albumin to creatinine ratio (uACR) were found in the maternal risk group compared to the nonmaternal risk group (p = .038). Multiple regression analysis in the maternal risk group revealed diastolic blood pressure (R = 0.159; β = 0.293; p = .050), carotid femoral PWV (R = 0.158; β = 0.297; p = .038) and carotid dorsalis pedis PWV (adj R = 0.322; β = 0.505; p < .001) to be positively associated with TBARS, while an inverse association of uACR (R = 0.161; β = -0.261; p = .046) with TBARS was observed. Also, in the maternal risk group, independent associations of DBP (R = 0.273; β = 0.289; p = .040) and uACR (R = 0.283; β = 0.268; p = .027) with 8-OHdG were indicated. In boys, as young as 6 years of age, oxidative stress related to arterial stiffness and diastolic blood pressure was observed. This association was only evident in boys with linked maternal lifestyle and cardiovascular risk factors, suggesting potential family-related early onset of cardiovascular risk.
早期心血管疾病（CVD）的发生可能受到家族性心血管和生活方式风险因素的影响。我们旨在比较按母亲心血管和生活方式风险分层的男孩的表型特征，并探讨氧化应激与血管功能之间的关联。我们纳入了 40 名黑人男孩和 41 名白人男孩（年龄 6-8 岁），以及每个孩子的生物母亲。根据母亲自我报告的心血管和生活方式风险因素预先确定的母亲风险，将研究人群分为两组（非母亲风险与母亲风险）。在不同部位测量脉搏波速度（PWV）并记录血压。收集尿液样本进行分析，以测定硫代巴比妥酸反应物质（TBARS）、8-羟基-2-脱氧鸟苷（8-OHdG）、白蛋白和肌酐。与非母亲风险组相比，母亲风险组的尿白蛋白与肌酐比值（uACR）更高（p=0.038）。在母亲风险组中，舒张压（R=0.159；β=0.293；p=0.050）、颈股 PWV（R=0.158；β=0.297；p=0.038）和颈背 PWV（调整后的 R=0.322；β=0.505；p<0.001）与 TBARS 呈正相关，而 uACR（R=0.161；β=-0.261；p=0.046）与 TBARS 呈负相关。此外，在母亲风险组中，DBP（R=0.273；β=0.289；p=0.040）和 uACR（R=0.283；β=0.268；p=0.027）与 8-OHdG 独立相关。在男孩中，即使在 6 岁时，也观察到与动脉僵硬和舒张压相关的氧化应激。这种关联仅在具有相关母亲生活方式和心血管风险因素的男孩中明显，表明潜在的与家庭相关的心血管风险的早期发生。
