Alsabti E A
Neoplasma. 1979;26(5):611-5.
Forty-five patients with acute myelogenous leukemia have been followed sequentially for 12 months. All these patients had serum immunoglobulin IgA, IgG, IgM and IgE levels measured by immunodiffusion and radioimmunoassay prior to chemotherapy, then every month after chemotherapy. Significant differences were found in IgA and IgG levels prior chemotherapy, while no differences were found in IgM or IgE levels at any time. There was a positive correlation between percentage of blasts and IgA level. There was negative correlation between the percentage of blasts and IgM levels. These findings raise the value of measuring the levels of immunoglobulins in patients with leukemia as a guide to the subclinical relapse of the disease. These results may also support the hypothesis of the role of early immune defect in immunoglobulin metabolism in the pathogenesis of acute leukemia.
45例急性髓性白血病患者已连续随访12个月。所有这些患者在化疗前通过免疫扩散和放射免疫测定法测量血清免疫球蛋白IgA、IgG、IgM和IgE水平，然后在化疗后每月测量一次。化疗前IgA和IgG水平存在显著差异，而IgM或IgE水平在任何时候均无差异。原始细胞百分比与IgA水平呈正相关。原始细胞百分比与IgM水平呈负相关。这些发现提高了测量白血病患者免疫球蛋白水平作为疾病亚临床复发指标的价值。这些结果也可能支持早期免疫缺陷在急性白血病发病机制中免疫球蛋白代谢作用的假说。
