Alsabti E A
J Surg Oncol. 1979;11(2):129-33. doi: 10.1002/jso.2930110206.
Eighty-one women admitted for breast tumor biopsy have been followed sequentially for 12 months. Thirty-one women had clinical stage I and II breast cancer and 50 had benign breast disease. All these women had serum immunoglobulin IgA, IgG, IgM and IgE levels measured by immunodiffusion and radioimmunoassay preoperatively, two weeks postoperatively, then three months, six months, nine months and twelve months postoperatively. Significant differences were found in IgA and IgG levels preoperatively in the cancer group while no differences were found in IgM or IgE levels at any time. There was positive correlation between the extent of metastatic breast cancer and IgA level. There was negative correlation between the extent of metastatic breast cancer and IgM levels. These findings raise the value of measuring the levels of immunoglobulins in patients with breast cancer as a guide to subclinical spread of the disease. The results may also support the hypothesis of the role of early immune defect in immunoglobulin metabolism in the pathogenesis of breast cancer.
81名因乳腺肿瘤活检入院的女性被连续随访了12个月。31名女性患有临床I期和II期乳腺癌，50名患有良性乳腺疾病。所有这些女性在术前、术后两周、术后三个月、六个月、九个月和十二个月均通过免疫扩散和放射免疫测定法测量血清免疫球蛋白IgA、IgG、IgM和IgE水平。癌症组术前IgA和IgG水平存在显著差异，而IgM或IgE水平在任何时候均无差异。转移性乳腺癌的范围与IgA水平呈正相关。转移性乳腺癌的范围与IgM水平呈负相关。这些发现提高了测量乳腺癌患者免疫球蛋白水平作为疾病亚临床扩散指标的价值。结果也可能支持早期免疫缺陷在乳腺癌发病机制中免疫球蛋白代谢作用的假说。
