Emerg Infect Dis. 2018 Feb;24(2):201-209. doi: 10.3201/eid2402.171407.
Human adenovirus type 4 (HAdV-4) is most commonly isolated in military settings. We conducted detailed molecular characterization on 36 HAdV-4 isolates recovered from civilian adults with acute respiratory disease (ARD) in the northeastern United States during 2011-2015. Specimens came from college students, residents of long-term care facilities or nursing homes, a cancer patient, and young adults without co-morbidities. HAdV-4 genome types 4a1 and 4a2, the variants most frequently detected among US military recruits in basic training before the restoration of vaccination protocols, were isolated in most cases. Two novel a-like variants were recovered from students enrolled at a college in Tompkins County, New York, USA, and a prototype-like variant distinguishable from the vaccine strain was isolated from an 18-year-old woman visiting a physician's office in Ulster County, New York, USA, with symptoms of influenza-like illness. Our data suggest that HAdV-4 might be an underestimated causative agent of ARD among civilian adults.
人腺病毒 4 型（HAdV-4）最常从军事环境中分离出来。我们对 2011 年至 2015 年间在美国东北部因急性呼吸道疾病（ARD）而住院的 36 例平民成年人的 HAdV-4 分离株进行了详细的分子特征分析。标本来自大学生、长期护理机构或疗养院的居民、一名癌症患者和没有合并症的年轻成年人。在疫苗接种方案恢复之前，在美国新兵基础训练中最常检测到的腺病毒 4 型 4a1 和 4a2 基因组类型，在大多数情况下都被分离出来。两种新型的类似 a 型的变异体从纽约州汤普金斯县一所大学的学生中分离出来，从纽约州阿尔斯特县一名 18 岁女性的医生办公室中分离出一种与疫苗株不同的类似原型变异体，该女性因流感样疾病就诊。我们的数据表明，HAdV-4 可能是平民成年人 ARD 的一个被低估的致病因子。
