血管收缩剂或水浸刺激可使大鼠心房肽释放，这与右心房压力的变化相关。

Release of atriopeptin in the rat by vasoconstrictors or water immersion correlates with changes in right atrial pressure.

作者信息

Katsube N, Schwartz D, Needleman P

出版信息

Biochem Biophys Res Commun. 1985 Dec 31;133(3):937-44. doi: 10.1016/0006-291x(85)91226-4.

Abstract

Vasopressin, its 1-deamino analog (dAVP), angiotensin II, and phenylephrine, administered intravenously, increased plasma atriopeptin immunoreactivity in chloral hydrate-anesthetized rats. A continuous one hour infusion of either dAVP or phenylephrine caused a sustained elevation in: a) systemic blood pressure; b) right atrial pressure; c) left ventricular end diastolic pressure; and d) plasma atriopeptin immunoreactivity. While continuous infusion of angiotensin II also produced a sustained elevation in left ventricular end diastolic pressure, the changes in right atrial pressure and plasma atriopeptin were only transient. These data suggest that plasma atriopeptin most closely correlates with right atrial pressure. Consistent with this hypothesis, we found that the release of atriopeptin directly correlated with changes in right atrial pressure in anesthetized, water-immersed rats.

摘要

静脉注射加压素、其1-去氨基类似物（dAVP）、血管紧张素II和去氧肾上腺素，可使水合氯醛麻醉大鼠的血浆心钠素免疫反应性升高。持续1小时输注dAVP或去氧肾上腺素会导致以下各项持续升高：a）体循环血压；b）右心房压力；c）左心室舒张末期压力；d）血浆心钠素免疫反应性。虽然持续输注血管紧张素II也会使左心室舒张末期压力持续升高，但右心房压力和血浆心钠素的变化只是短暂的。这些数据表明，血浆心钠素与右心房压力的相关性最为密切。与此假设一致的是，我们发现，在麻醉的水浸大鼠中，心钠素的释放与右心房压力的变化直接相关。