Federal University of Pelotas, Postgraduate Program in Epidemiology, Pelotas, Brazil.
Instituto Nacional de Enfermedades Respiratorias, Institute of Respiratory Diseases, Mexico City, Mexico.
PLoS One. 2019 Jun 27;14(6):e0219077. doi: 10.1371/journal.pone.0219077. eCollection 2019.
The objective was to verify the association between body composition from 18 to 22 years and pulmonary function at 22 years of age. This longitudinal analysis was conducted with a Brazilian birth cohort data. The outcomes were the forced expiratory volume in the first second and forced vital capacity (FVC), measured at 22 years follow-up. Main exposures: obesity (body mass index ≥ 30kg/m2), and highest tertiles of fat mass (FM) and fat mass index (air displacement plethysmography) measured at 18 and 22 years-old follow-ups. The reference category (not exposed) was defined by those individuals who were not classified in the highest adiposity categories mentioned, in both ages. Multivariable linear regressions stratified by sex were used. The sample comprised 3,511 participants. Those who belonged to the highest adiposity categories in 18 and 22 years follow-ups showed lower pulmonary function at 22 years when compared to those who were not classified in the higher adiposity categories in both ages (reference category); those in the highest tertile of FM showed a mean FVC -313mL (95%CI -421; -206) and -259mL (95%CI -336; -182) in men and women, compared to the reference category, respectively. Those who changed from the higher to the lower adiposity categories (from 18 to 22 years) showed pulmonary function similar to the reference, and those who presented the opposite body composition trajectory, showed decreased pulmonary function results at 22 years, mainly among women. We concluded that high body adiposity in two follow-ups and especially contemporary adiposity was associated with lower pulmonary function at 22 years.
目的是验证 18 至 22 岁时的身体成分与 22 岁时的肺功能之间的关联。这项纵向分析是使用巴西出生队列数据进行的。结局是在 22 年随访时测量的第一秒用力呼气量和用力肺活量（FVC）。主要暴露因素：肥胖（体重指数≥30kg/m2），以及在 18 岁和 22 岁随访时测量的脂肪量（FM）和脂肪量指数（空气置换体描记法）的最高三分位数。参考类别（未暴露）定义为在两个年龄组中均未归入上述最高肥胖类别者。采用按性别分层的多变量线性回归。该样本包括 3511 名参与者。与在两个年龄组中均未归入更高肥胖类别的个体相比，18 岁和 22 岁时属于最高肥胖类别的个体在 22 岁时的肺功能较低（参考类别）；与参考类别相比，FM 最高三分位数的男性和女性的 FVC 分别降低了 313mL（95%CI -421；-206）和 259mL（95%CI -336；-182）。那些从较高肥胖类别转变为较低肥胖类别的人（18 岁至 22 岁）的肺功能与参考相似，而那些身体成分轨迹相反的人在 22 岁时肺功能下降，主要是女性。我们得出结论，两个随访时间的高身体肥胖和特别是当代肥胖与 22 岁时的较低肺功能相关。
