Centre for Trophoblast Research, Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, CB2 3EG, UK.
Placenta. 2018 Apr;64 Suppl 1:S16-S22. doi: 10.1016/j.placenta.2018.01.005. Epub 2018 Jan 11.
During pregnancy, the fetus requires nutrients supplied by the mother to grow and develop. However, the mother also requires sufficient resources to support the pregnancy, as well as, to maintain her health. Failure to regulate resource allocation between the mother and fetus can lead to pregnancy complications with immediate and life-long consequences for maternal and offspring health. This review explores the role of insulin-like growth factor (IGF)-2 in regulating materno-fetal resource allocation, particularly via its regulation of placental development and function.
在怀孕期间，胎儿需要从母亲那里获得营养来生长和发育。然而，母亲也需要足够的资源来支持妊娠，并维持她的健康。如果不能调节母亲和胎儿之间的资源分配，就会导致妊娠并发症，对母婴健康产生即时和终身的影响。本综述探讨了胰岛素样生长因子（IGF）-2 在调节母婴资源分配方面的作用，特别是通过其对胎盘发育和功能的调节。
