Zubcevic Jasenka, Watkins Jacqueline, Lin Cindy, Bautista Byrell, Hatch Heather M, Tevosian Sergei G, Hayward Linda F
Department of Physiology and Pharmacology, University of Toledo College of Medicine, Toledo, OH 43614, USA.
Department of Physiological Sciences, University of Florida College of Veterinary Medicine, Gainesville, FL 32610, USA.
Metabolites. 2022 Aug 9;12(8):735. doi: 10.3390/metabo12080735.
Tobacco smoking is the leading cause of preventable death. Numerous reports link smoking in pregnancy with serious adverse outcomes, such as miscarriage, stillbirth, prematurity, low birth weight, perinatal morbidity, and infant mortality. Corollaries of consuming nicotine in pregnancy, separate from smoking, are less explored, and the mechanisms of nicotine action on maternal-fetal communication are poorly understood. This study examined alterations in the maternal gut microbiome in response to nicotine exposure during pregnancy. We report that changes in the maternal gut microbiota milieu are an important intermediary that may mediate the prenatal nicotine exposure effects, affect gene expression, and alter fetal exposure to circulating short-chain fatty acids (SCFAs) and leptin during in utero development.
吸烟是可预防死亡的主要原因。众多报告将孕期吸烟与严重不良后果联系起来，如流产、死产、早产、低出生体重、围产期发病率和婴儿死亡率。孕期摄入尼古丁（与吸烟无关）的相关影响研究较少，且对尼古丁影响母婴交流的机制了解不足。本研究调查了孕期尼古丁暴露对母体肠道微生物群的影响。我们报告称，母体肠道微生物群环境的变化是一个重要的中介因素，可能介导产前尼古丁暴露的影响，影响基因表达，并在子宫内发育期间改变胎儿对循环短链脂肪酸（SCFAs）和瘦素的暴露。
