Sehnal B, Rozsypal H, Nipčová M, Sláma J
Epidemiol Mikrobiol Imunol. 2017 Fall;66(4):198-209.
Human papillomavirus (HPV) is the most common sexually transmitted infection worldwide, which may result in the development of benign or malignant tumours. HPV infec-tions cause approximately 5% of all human cancers. Infection at all sites is strongly associated with sexual behaviour, but this association does not appear to explain substantial differences in the prevalence, incidence, persistence, and clearance of HPV infection in the anal, genital, and oral areas. Discussed are the similarities and differences among the natural histories of infection in different anatomical sites of the human body of both genders. Despite the huge advances already achieved, more research is needed to suggest effective prevention strategies (including the screening of high-risk groups and vaccination) for HPV infection and associated diseases.
人乳头瘤病毒（HPV）是全球最常见的性传播感染，可能导致良性或恶性肿瘤的发生。HPV感染约占所有人类癌症的5%。所有部位的感染都与性行为密切相关，但这种关联似乎并不能解释肛门、生殖器和口腔部位HPV感染的患病率、发病率、持续时间和清除率的显著差异。本文讨论了男女两性人体不同解剖部位感染自然史的异同。尽管已经取得了巨大进展，但仍需要更多研究来提出针对HPV感染及相关疾病的有效预防策略（包括对高危人群进行筛查和接种疫苗）。
