Department of Rheumatology and Immunology, The Second Xiangya Hospital of Central South University, Changsha, China.
Clin Exp Rheumatol. 2018 May-Jun;36(3):442-447. Epub 2018 Jan 15.
The aim of this study is to explore whether the polymorphisms of rs475688 and rs3825016 in the solute carrier family 22 member 12 (SLC22A12) gene are associated with the susceptibility to gout or hyperuricaemia.
Relevant studies were enrolled by searching databases systematically. The pooled odds ratios (ORs) with 95% confidence interval (CI) were used to evaluate the associations. Q-test and I2 statistics were used to evaluate the heterogeneity. Publication bias was evaluated using Begg's funnel plots and Egger regression test.
A total of 7 articles involving 1216 patients and 1844 healthy controls were included in this meta-analysis. Significant association was detected between rs475688 polymorphism and gout susceptibility in three genetic models (C vs. T: OR=1.464, 95% CI 1.078-1.989, p=0.015; CC+CT vs. TT: OR=2.028, 95% CI 1.488-2.763, p=0.000; CC vs. CT+TT: OR=2.226, 95% CI 1.746-2.838, p=0.000). Significant association was observed between rs3825016 polymorphism and hyperuricaemia susceptibility only in allelic comparison (C vs. T: OR=1.274, 95% CI 1.101-1.474, p=0.001).
The rs475688 polymorphism is associated with gout susceptibility. The correlation between rs3825016 polymorphism of SLC22A12 and hyperuricaemia susceptibility is possible.
本研究旨在探讨溶质载体家族 22 成员 12（SLC22A12）基因中的 rs475688 和 rs3825016 多态性是否与痛风或高尿酸血症易感性相关。
通过系统检索数据库，纳入相关研究。采用合并优势比（OR）及其 95%置信区间（CI）评估相关性。采用 Q 检验和 I² 统计量评估异质性。采用 Begg 漏斗图和 Egger 回归检验评估发表偏倚。
本荟萃分析共纳入 7 项研究，包括 1216 例患者和 1844 例健康对照。在三种遗传模型中，rs475688 多态性与痛风易感性显著相关（C 与 T 相比：OR=1.464，95%CI 1.078-1.989，p=0.015；CC+CT 与 TT 相比：OR=2.028，95%CI 1.488-2.763，p=0.000；CC 与 CT+TT 相比：OR=2.226，95%CI 1.746-2.838，p=0.000）。仅在等位基因比较中，rs3825016 多态性与高尿酸血症易感性显著相关（C 与 T 相比：OR=1.274，95%CI 1.101-1.474，p=0.001）。
rs475688 多态性与痛风易感性相关。SLC22A12 基因的 rs3825016 多态性与高尿酸血症易感性可能相关。
