Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA.
Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.
Alzheimers Dement. 2018 Jun;14(6):734-742. doi: 10.1016/j.jalz.2017.12.003. Epub 2018 Jan 18.
We compared risk of progression from subjective cognitive decline (SCD) to mild cognitive impairment (MCI) in an academic memory clinic versus a population-based study.
Older adults presenting at a memory clinic were classified as SCD (n = 113) or as noncomplainers (n = 82). Participants from a population study were classified as SCD (n = 592) and noncomplainers (n = 589) based on a memory complaint score. Annual follow-up performed for a mean of 3 years.
The adjusted hazard ratio for SCD was 15.97 (95% confidence interval: 6.08-42.02, P < .001) in the memory clinic versus 1.18 (95% confidence interval: 1.00-1.40, P = .047) in the population study, where reported "worry" about memory further increased SCD-associated risk for MCI.
SCD is more likely to progress to MCI in a memory clinic than the general population; participants' characteristics vary across settings. Study setting should be considered when evaluating SCD as a risk state for MCI and dementia.
我们比较了在学术记忆诊所和基于人群的研究中，从主观认知下降（SCD）进展为轻度认知障碍（MCI）的风险。
在记忆诊所就诊的老年人被分为 SCD（n=113）或非抱怨者（n=82）。基于记忆抱怨评分，人群研究中的参与者被分为 SCD（n=592）和非抱怨者（n=589）。平均随访 3 年。
与人群研究中的 1.18（95%置信区间：1.00-1.40，P=0.047）相比，记忆诊所中的 SCD 的调整后危险比为 15.97（95%置信区间：6.08-42.02，P<0.001），报告“担心”记忆进一步增加了与 MCI 相关的 SCD 风险。
与一般人群相比，SCD 在记忆诊所更有可能进展为 MCI；参与者的特征在不同环境中有所不同。在评估 SCD 作为 MCI 和痴呆的风险状态时，应考虑研究环境。
