青钱柳叶多糖组分对高脂乳剂诱导的高血脂模型小鼠的降血脂和保肝作用。
Antihyperlipidemic and hepatoprotective activities of polysaccharide fraction from Cyclocarya paliurus in high-fat emulsion-induced hyperlipidaemic mice.
机构信息
Key Lab for Agro-product Processing and Quality Control of Nanchang City, College of Food Science and Engineering, Jiangxi Agricultural University, Nanchang, 330045, China.
College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang, 330045, China.
出版信息
Carbohydr Polym. 2018 Mar 1;183:11-20. doi: 10.1016/j.carbpol.2017.11.033. Epub 2017 Nov 10.
The objective of this study was to analyse the structure of CPP-2, and to observe the pharmacological effects of CPP-2 on lipid metabolism and oxidative stress. CPP-2, eluted as two main fractions comprised of two polysaccharides with Mw of 307 and 3.7kDa, was mainly consisted of rhamnose, mannose, glucose and galactose in a molar ratio of 1.00:0.78:3.22:0.45. The results showed that treatment with CPP-2 could improve blood lipid levels (TC, TG, HDL-C and LDL-C), liver lipid levels (TC and TG) and antioxidant status (SOD, T-AOC, GSH-PX, MDA and LPO). In addition, the histopathological observations of mice livers and the GPT activities indicated that CPP-2 could attenuate liver cell injury. The present findings demonstrated that CPP-2 might be effective in lowering lipid and protecting against HFE-induced hyperlipidemia and non-alcoholic fatty liver.
本研究旨在分析 CPP-2 的结构，并观察 CPP-2 对脂代谢和氧化应激的药理作用。CPP-2 洗脱后得到两个主要部分，均由两种多糖组成，Mw 分别为 307 和 3.7kDa，主要由鼠李糖、甘露糖、葡萄糖和半乳糖组成，摩尔比为 1.00:0.78:3.22:0.45。结果表明，CPP-2 可改善血脂水平（TC、TG、HDL-C 和 LDL-C）、肝脂水平（TC 和 TG）和抗氧化状态（SOD、T-AOC、GSH-PX、MDA 和 LPO）。此外，小鼠肝脏的组织病理学观察和 GPT 活性表明，CPP-2 可减轻肝细胞损伤。本研究结果表明，CPP-2 可能有效降低血脂，预防 HFE 诱导的高脂血症和非酒精性脂肪肝。
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